Obstructive sleep apnea, immuno-inflammation, and atherosclerosis

Autor: Jean-Philippe Baguet, Patrick Levy, Claire Arnaud, Jean-Louis Pépin, Maurice Dematteis
Přispěvatelé: Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire du sommeil et EFCR, CHU Grenoble, Radiopharmaceutiques biocliniques, Département de cardiologie et hypertension, CHU Grenoble-Hôpital Michallon, This work was supported by a grant from AGIR@dom to CA and MD. CA is recipient of fellowship from the Fondation pour la Recherche Médicale (France)., Arnaud, Claire
Rok vydání: 2009
Předmět:
MESH: Inflammation
MESH: Oxidation-Reduction
MESH: Sleep Apnea
Obstructive
MESH: Anoxia
chemokines
030204 cardiovascular system & hematology
MESH: Atherosclerosis
Renin-Angiotensin System
0302 clinical medicine
MESH: Renin-Angiotensin System
Immunology and Allergy
MESH: Animals
Endothelial dysfunction
Hypoxia
obstructive sleep apnea
Sleep Apnea
Obstructive
Sleep disorder
Sleep apnea
Intermittent hypoxia
adipose tissue
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
3. Good health
MESH: Insulin Resistance
Cardiology
MESH: Vasoconstriction
MESH: Endothelium
Vascular
medicine.symptom
Oxidation-Reduction
medicine.medical_specialty
intermittent hypoxia
Immunology
Inflammation
Article
03 medical and health sciences
MESH: Adipokines
Adipokines
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
medicine
Animals
Humans
Dyslipidemias
MESH: Humans
business.industry
MESH: Dyslipidemias
Hypoxia (medical)
medicine.disease
Obstructive sleep apnea
Endocrinology
030228 respiratory system
Vasoconstriction
inflammation
Endothelium
Vascular
Insulin Resistance
atherosclerosis
business
Dyslipidemia
Zdroj: Seminars in Immunopathology
Seminars in Immunopathology, 2009, 31 (1), pp.113-25. ⟨10.1007/s00281-009-0148-5⟩
Seminars in Immunopathology, Springer Verlag, 2009, 31 (1), pp.113-25. ⟨10.1007/s00281-009-0148-5⟩
ISSN: 1863-2300
1863-2297
DOI: 10.1007/s00281-009-0148-5
Popis: International audience; Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder leading to cardiovascular and metabolic complications. OSA is also a multicomponent disorder, with intermittent hypoxia (IH) as the main trigger for the associated cardiovascular and metabolic alterations. Indeed, recurrent pharyngeal collapses during sleep lead to repetitive sequences of hypoxia-reoxygenation. This IH induces several consequences such as hemodynamic, hormonometabolic, oxidative, and immuno-inflammatory alterations that may interact and aggravate each other, resulting in artery changes, from adaptive to degenerative atherosclerotic remodeling. Atherosclerosis has been found in OSA patients free of other cardiovascular risk factors and is related to the severity of nocturnal hypoxia. Early stages of artery alteration, including functional and structural changes, have been evidenced in both OSA patients and rodents experimentally exposed to IH. Impaired vasoreactivity with endothelial dysfunction and/or increased vasoconstrictive responses due to sympathetic, endothelin, and renin-angiotensin systems have been reported and also contribute to vascular remodeling and inflammation. Oxidative stress, inflammation, and vascular remodeling can be directly triggered by IH, further aggravated by the OSA-associated hormonometabolic alterations, such as insulin resistance, dyslipidemia, and adipokine imbalance. As shown in OSA patients and in the animal model, genetic susceptibility, comorbidities (obesity), and life habits (high fat diet) may aggravate atherosclerosis development or progression. The intimate molecular mechanisms are still largely unknown, and their understanding may contribute to delineate new targets for prevention strategies and/or development of new treatment of OSA-related atherosclerosis, especially in patients at risk for cardiovascular disease.
Databáze: OpenAIRE
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