Lipopolysaccharides: Structural Principles and Biologic Activities

Autor:	Helmut Brade, Tetsuo Shiba, Shoichi Kusumoto, Ulrich Zähringer, G R McKenzie, Chris Galanos, Ernst Th. Rietschel, O Lüderitz, K Tanamoto
Rok vydání:	1984
Předmět:	Lipopolysaccharides Microbiology (medical) Lipopolysaccharide Pyrogens business.industry Lipid A Mice Structure-Activity Relationship chemistry.chemical_compound Infectious Diseases chemistry Biochemistry Animals Structure–activity relationship Medicine Rabbits Mitogens business
Zdroj:	Clinical Infectious Diseases. 6:428-431
ISSN:	1537-6591 1058-4838
Popis:	Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however, needed for expression of effects similar to those of lipid A were about 500 times higher. These investigations are aimed at verifying the proposed structure of lipid A and at evaluating structure-activity relationships.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef083e2da95dc10a48cd323c4dee5c7 https://doi.org/10.1093/clinids/6.4.428 Zobrazit plný text záznamu