Contribution of Toll-Like Receptor 9 Gene Single-Nucleotide Polymorphism to Systemic Lupus Erythematosus in Egyptian Patients

Autor:	Rania H. Khalifa, Engy El Khateeb, Rasha M. El Refai, Rasha Mohamad Hosny Shahin
Rok vydání:	2016
Předmět:	Adult Genotype Immunology Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences Young Adult 0302 clinical medicine Gene Frequency immune system diseases parasitic diseases medicine Odds Ratio SNP Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Allele skin and connective tissue diseases Allele frequency Alleles Genetic Association Studies 030203 arthritis & rheumatology Autoimmune disease business.industry Case-control study General Medicine medicine.disease Phenotype Case-Control Studies Toll-Like Receptor 9 Egypt Female business 030215 immunology Anti-SSA/Ro autoantibodies
Zdroj:	Immunological investigations. 45(3)
ISSN:	1532-4311
Popis:	Systemic lupus erythematosus (SLE) is an autoimmune disease, with multiple genetic and environmental factors involved in its etiology. The toll-like receptor 9 (TLR9) gene has been reported to have important roles in the development and progression of SLE. In this case-control study, the effect of TLR9 polymorphism on susceptibility to SLE was investigated in Egyptian patients.We studied the distribution of the TLR9 rs352139 (G + 1174A) single nucleotide polymorphism (SNP) by allele-specific polymerase chain reaction (PCR) in 104 Egyptian patients with SLE and 108 age-, sex-, and ethnically matched controls.There was no statistically significant difference in the distribution of the AA genotype and alleles between SLE patients and the control group in our study; however, the GA heterozygous patients were three times more likely to develop SLE (P0.001). A significant association was detected between TLR9 genotypes and some of the disease manifestations as myositis (p = 0.032), psychosis (p = 0.014), photosensitivity (p = 0.002), and pleurisy (p =0.001). Moreover, we observed a significant association between the TLR9 AA and GA genotypes and the presence of antinuclear antibodies (ANA) (p = 0.038).The G + 1174A SNP in the toll receptor 9 gene may contribute to the genetic susceptibility of SLE in Egyptian patients. Also, an influence for this polymorphism on disease manifestations has been elucidated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef04a6f705c9125cfcaa9773f78f69f https://pubmed.ncbi.nlm.nih.gov/27018624 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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