Incidence rates and characteristics of pediatric onset psychogenic nonepileptic seizures
| Autor: | Maria Rodrigo-Domingo, Jakob Christensen, Sofie Gry Pristed, Charlotte Ulrikka Rask, René Ernst Nielsen, Anne Sofie Hansen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Adolescent Pediatric onset Denmark Population MEDLINE Child Behavior Comorbidity Risk Assessment 03 medical and health sciences Epilepsy 0302 clinical medicine Child Development Risk Factors Seizures 030225 pediatrics Health care Medicine Psychogenic disease Humans Age of Onset education Child education.field_of_study business.industry Medical record Incidence (epidemiology) Incidence Age Factors Adolescent Development medicine.disease Mental Health Adolescent Behavior Neurodevelopmental Disorders Child Preschool Pediatrics Perinatology and Child Health Female business 030217 neurology & neurosurgery |
| Zdroj: | Hansen, A S, Rask, C U, Rodrigo-Domingo, M, Pristed, S G, Christensen, J & Nielsen, R E 2020, ' Incidence rates and characteristics of pediatric onset psychogenic nonepileptic seizures ', Pediatric Research, vol. 88, no. 5, pp. 796-803 . https://doi.org/10.1038/s41390-020-0945-z Hansen, A S, Rask, C U, Domingo, M R, Pristed, S G, Christensen, J & Nielsen, R E 2020, ' Incidence rates and characteristics of pediatric onset psychogenic nonepileptic seizures ', Pediatric Research, vol. 88, no. 5, pp. 796–803 . https://doi.org/10.1038/s41390-020-0945-z |
| DOI: | 10.1038/s41390-020-0945-z |
| Popis: | BACKGROUND: Pediatric onset psychogenic nonepileptic seizures (PNES) is a highly disabling disorder and potentially misdiagnosed as epilepsy. Still, knowledge regarding PNES in children and adolescents is limited and data on both incidence and characteristics are scarce. This study investigated the incidence rate (IR) and clinical characteristics of pediatric onset PNES, including possible differences when having comorbid epilepsy.METHODS: A population-based study of children and adolescents aged 5-17 years with an incident diagnosis of PNES in the Danish healthcare registries between 1996 and 2014. In total, 386 children and adolescents were included after assessment of diagnostic validity using medical record data.RESULTS: The IR increased during the study period with the maximum IR observed in 2014 (7.4 per 100,000 person-years). A history of both neurologic and psychiatric problems as well as negative life events was identified. Comorbid epilepsy was confirmed for 55 cases (14.2%) and was associated with intellectual disabilities, school support and prolonged delay in PNES diagnosis.CONCLUSIONS: PNES are increasingly diagnosed in children and adolescents, and the clinical profile of both neurologic and psychiatric health problems underscores the need for collaborative pediatric and mental healthcare. These findings provide important information for future healthcare planning in this area.IMPACT: This nationwide study is the first to report population-based incidence rates of pediatric onset PNES documenting markedly increasing incidence rates between 1996 and 2014. A history of both neurologic and psychiatric problems as well as negative life events was identified for pediatric onset PNES. Comorbid epileptic seizures were associated with intellectual disabilities, school support and prolonged delay in PNES diagnosis. The clinical profile of both neurologic and psychiatric health problems underscores the need for collaborative pediatric and mental healthcare. The increasing number of children and adolescents diagnosed with PNES is important information for future healthcare planning in this area. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|