Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated fromTiarella polyphylla
| Autor: | Jung Joon Lee, Hyeong Kyu Lee, Sei-Ryang Oh, Si Hyung Park, Jae Gil Kim, Im Seon Lee, Keun Young Jung, Kyung-Seop Ahn |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Complement Inactivator Proteins Korea Magnetic Resonance Spectroscopy Plants Medicinal Plant Extracts Chemistry Stereochemistry Organic Chemistry Pharmacology toxicology Glycoside Tiarella polyphylla Saponins chemistry.chemical_compound Triterpene Drug Discovery Humans Molecular Medicine Complement Pathway Classical Glycosides Oleanolic Acid Spectral data Oleanolic acid Volume concentration |
| Zdroj: | Archives of Pharmacal Research. 22:428-431 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02979071 |
| Popis: | Seven known oleanolic acid glycosides (1-7) were isolated from the MeOH extract of Tiarella polyphylla. The structures were identified to be 3-O-(beta-D-glucopyranosyl) oleanolic acid (1), 3-O-[beta-D-glucopyranosyl-(1--3)-beta-D-glucopyranosyl] oleanolic acid (2), 3-O-[beta-D-glucopyranosyl-(1--2)-beta-D-glucopyranosyl] oleanolic acid (3), 3-O-[beta-D-glucopyranosyl-(1--3)-beta-D-glucopyranosyl] oleanolic acid 28-O-beta-D-glucopyranosyl ester (4), 3-O-[beta-D-glucopyranosyl-(1--2)-beta-D-glucopyranosyl] oleanolic acid 28-O-beta-D-glucopyranosyl ester (5), 3-O-[a-L-rhamnopyranosyl-(1--3)-beta-D-glucuronopyranosyl] oleanolic acid (6), and 3-O-[alpha-L-rhamnopyranosyl-(1--3)-beta-D-glucuronopyranosyl] oleanolic acid 28-O-beta-D-glucopyranosyl ester (7) on the basis of physicochemical and spectral data. These triterpene glycosides were tested for the anticomplement activity and hemolytic activity. Bisdesmosidic saponins, 4, 5, and 7, showed anticomplement activity; in contrast, monodesmosidic saponins, 1-3, and 6, showed direct hemolytic activity. Methyl esterified monodesmosidic saponins showed anticomplement activity at a low concentration and hemolytic activity at a high concentration. |
| Databáze: | OpenAIRE |
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