Effects of voice rehabilitation in people with MS: A double-blinded long-term randomized controlled trial
| Autor: | Arianna Napoletano, Chiara Vitali, Laura Tomasoni, Valeria Crispiatico, Cinzia Baldanzi, Davide Cattaneo, Francesca Tedeschi, Elisabetta Groppo, Marco Rovaris |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Double blinded business.industry Multiple sclerosis Hypophonia Parkinson Disease medicine.disease Term (time) law.invention Treatment Outcome Voice Training Physical medicine and rehabilitation Neurology Randomized controlled trial law Humans Medicine Neurology (clinical) medicine.symptom business Voice rehabilitation |
| Zdroj: | Multiple Sclerosis Journal. 28:1081-1090 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/13524585211051059 |
| Popis: | Background: Hypophonia is a prevailing problem in people with multiple sclerosis (PwMS). However, evidence supporting the effectiveness of voice rehabilitation is lacking. Objective: The aim of this study was to identify the most effective method to reduce hypophonia. Methods: In this randomized controlled trial, 44 PwMS were randomized to intensive and high-effort voice treatment groups, the LSVT-LOUD®, and conventional treatment group. Subjects received 16 treatments (4 sessions/week) lasting 45 minutes. The primary outcome was voice intensity (dB) in monologue, vocalization, and sentences while voice handicap index (VHI) measured voice self-perception. Outcomes were assessed by a blinded observer at baseline, post-treatment, and 15-month follow-up (FU). Results: Linear models revealed a significant post-intervention between-group mean difference in favor of LSVT-LOUD for monologue: +6.3 dB (95% CI: 2.5 to 10.1); vocalization: +7.4 dB (95% CI: 2.3 to 12.5); and sentences: +9.5 dB (95% CI: 4.7 to 14.3). However, 43.7% PwMS in the LSVT-LOUD and 10% in the conventional treatment group obtained a full recovery of voice intensity (>60 dB) post-treatment, Fisher’s test = 13.3, p Conclusion: LSVT-LOUD can be a valid treatment to increase voice intensity in PwMS. However, results suggest the need for FU interventions targeting maintenance. |
| Databáze: | OpenAIRE |
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