Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men
Autor: | Sandra Vela, Boris Revollo, Arelly Ornelas, Marta Piñol, Guillem Sirera, Bonaventura Clotet, Sebastián Videla, Francesc García-Cuyás |
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Rok vydání: | 2018 |
Předmět: |
RNA viruses
Male Viral Diseases Electrosurgery medicine.medical_treatment lcsh:Medicine Imiquimod HIV Infections Single Center Pathology and Laboratory Medicine 0302 clinical medicine Immunodeficiency Viruses Recurrence Cytology Medicine and Health Sciences Public and Occupational Health 030212 general & internal medicine lcsh:Science education.field_of_study Multidisciplinary Pharmaceutics Human papillomavirus 11 virus diseases Anal canal Vaccination and Immunization medicine.anatomical_structure Infectious Diseases Treatment Outcome Anti-Retroviral Agents Medical Microbiology Condylomata Acuminata 030220 oncology & carcinogenesis Viral Pathogens Viruses Warts Pathogens medicine.drug Research Article Adult medicine.medical_specialty Human Papillomavirus Infection Adolescent Genotype Infrared Rays Urology Population Immunology Sexually Transmitted Diseases Antiretroviral Therapy Dermatology Microbiology 03 medical and health sciences Young Adult Signs and Symptoms Drug Therapy Antiviral Therapy Adjuvants Immunologic Diagnostic Medicine Retroviruses medicine Anal cancer Humans Homosexuality Male education Condyloma Acuminata Microbial Pathogens Retrospective Studies Anus Diseases business.industry Genitourinary Infections lcsh:R Lentivirus Organisms Biology and Life Sciences HIV Retrospective cohort study Cell Biology medicine.disease Human papillomavirus 6 Lesions lcsh:Q Preventive Medicine business |
Zdroj: | PLoS ONE r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname PLoS ONE, Vol 13, Iss 8, p e0199033 (2018) |
ISSN: | 1932-6203 |
Popis: | Background There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. Aim To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice. Methods Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed. Results Between January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2-15%) with electrosurgery excision, 11% (3/27, 95%CI: 4-28%) with infrared coagulation and 11% (1/9, 95%CI: 2-44%) with imiquimod treatment. No predictive factors were associated with recurrence. Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection. Conclusion Recurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up. |
Databáze: | OpenAIRE |
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