Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men

Autor: Sandra Vela, Boris Revollo, Arelly Ornelas, Marta Piñol, Guillem Sirera, Bonaventura Clotet, Sebastián Videla, Francesc García-Cuyás
Rok vydání: 2018
Předmět:
RNA viruses
Male
Viral Diseases
Electrosurgery
medicine.medical_treatment
lcsh:Medicine
Imiquimod
HIV Infections
Single Center
Pathology and Laboratory Medicine
0302 clinical medicine
Immunodeficiency Viruses
Recurrence
Cytology
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
lcsh:Science
education.field_of_study
Multidisciplinary
Pharmaceutics
Human papillomavirus 11
virus diseases
Anal canal
Vaccination and Immunization
medicine.anatomical_structure
Infectious Diseases
Treatment Outcome
Anti-Retroviral Agents
Medical Microbiology
Condylomata Acuminata
030220 oncology & carcinogenesis
Viral Pathogens
Viruses
Warts
Pathogens
medicine.drug
Research Article
Adult
medicine.medical_specialty
Human Papillomavirus Infection
Adolescent
Genotype
Infrared Rays
Urology
Population
Immunology
Sexually Transmitted Diseases
Antiretroviral Therapy
Dermatology
Microbiology
03 medical and health sciences
Young Adult
Signs and Symptoms
Drug Therapy
Antiviral Therapy
Adjuvants
Immunologic
Diagnostic Medicine
Retroviruses
medicine
Anal cancer
Humans
Homosexuality
Male
education
Condyloma Acuminata
Microbial Pathogens
Retrospective Studies
Anus Diseases
business.industry
Genitourinary Infections
lcsh:R
Lentivirus
Organisms
Biology and Life Sciences
HIV
Retrospective cohort study
Cell Biology
medicine.disease
Human papillomavirus 6
Lesions
lcsh:Q
Preventive Medicine
business
Zdroj: PLoS ONE
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
PLoS ONE, Vol 13, Iss 8, p e0199033 (2018)
ISSN: 1932-6203
Popis: Background There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. Aim To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice. Methods Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed. Results Between January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2-15%) with electrosurgery excision, 11% (3/27, 95%CI: 4-28%) with infrared coagulation and 11% (1/9, 95%CI: 2-44%) with imiquimod treatment. No predictive factors were associated with recurrence. Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection. Conclusion Recurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up.
Databáze: OpenAIRE
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