A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

Autor:	Hosahudya N. Gopi, Sachitanand M. Mali, Sushil N. Benke, Anupam Bandyopadhyay, Sandip V. Jadhav
Rok vydání:	2011
Předmět:	Models Molecular Dipeptide Molecular Structure Chemistry Stereochemistry Organic Chemistry Stereoisomerism Alcohol Tripeptide Crystallography X-Ray Amino Alcohols Biochemistry Pentapeptide repeat chemistry.chemical_compound Molecule Physical and Theoretical Chemistry Peptaibols
Zdroj:	Organic & Biomolecular Chemistry. 9:4182
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c0ob01226b
Popis:	A facile, efficient and racemization-free method for the synthesis of N-protected β-amino alcohols and peptaibols using N-hydroxysuccinimide active esters is described. Using this method, dipeptide, tripeptide and pentapeptide alcohols were isolated in high yields. The conformations in crystals of β-amino alcohol, dipeptide and tripeptide alcohols were analysed, with a well-defined type III β-turn being observed in the tripeptide alcohol crystals. This method is found to be compatible with Fmoc-, Boc- and other side-chain protecting groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eed832b34009a51246769c852a5b232 https://doi.org/10.1039/c0ob01226b Zobrazit plný text záznamu