Hypertension and antihypertensive treatment in HIV-infected individuals. A longitudinal cohort study

Autor:	Olav Oektedalen, Morten Baekken, Ingrid Os, Ingjerd W. Manner
Rok vydání:	2012
Předmět:	Adult Male medicine.medical_specialty Longitudinal study Diastole HIV Infections Disease Logistic regression Cohort Studies Excretion Risk Factors Internal medicine Internal Medicine Humans Medicine Longitudinal Studies Antihypertensive Agents business.industry Incidence Incidence (epidemiology) General Medicine Odds ratio Middle Aged Surgery Blood pressure Hypertension Female Cardiology and Cardiovascular Medicine business
Zdroj:	Blood Pressure. 21:311-319
ISSN:	1651-1999 0803-7051
DOI:	10.3109/08037051.2012.680742
Popis:	Hypertension is a significant contributor to cardiovascular disease in HIV-infected individuals. The purposes of this study were to assess the development of new-onset hypertension and the use of antihypertensive treatment and blood pressure (BP) control.In a longitudinal study of 434 HIV-infected individuals (43±11 years, 72% males, follow-up 3.4±0.8 years), standardized BP recordings were undertaken at three clinical visits both at baseline and at follow-up, and cardiovascular risk factors were monitored. Adjusted odds ratio (OR) for new-onset hypertension (systolic BP≥140 and/or diastolic BP≥90 mmHg or initiation of antihypertensive treatment) was calculated using multiple logistic regression analyses.New-onset hypertension occurred with an incidence of 29.8 per 1000 person-years (95% CI 20.3-42.2). HIV duration (OR=1.10, 95% CI 1.01-1.20), mean BP (1.24, 95% CI 1.13-1.35) and abnormal urinary albumin excretion (OR=5.47, 95% CI 1.07-27.85) were independent predictors for new-onset hypertension after adjustment. Use of antihypertensive treatment increased threefold from 17% to 49% in hypertensive patients. Adequate BP control was obtained in 22% of patients on antihypertensive therapy.HIV duration predicted new-onset hypertension, which could suggest involvement of low-grade inflammation; this hypothesis needs to be further explored. Despite increased use of antihypertensive treatment, enhanced awareness and adequate treatment of hypertension are still warranted in HIV-infected individuals.
Databáze:	OpenAIRE
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