Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams
| Autor: | Carolina Maria Quinello Gomes de Faria, Maicon Segalla Petrônio, Dulce Helena Siqueira Silva, Valdecir Farias Ximenes, Marcos Antonio Corrêa, Bruna Galdorfini Chiari, Luiz Marcos da Fonseca, Vera Lucia Borges Isaac, Luis Octávio Regasini, Ana Carolina Nazaré |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.drug_class
Anti-Inflammatory Agents Pharmaceutical Science Cosmetics medicine.disease_cause Anti-inflammatory Article Analytical Chemistry Ferulic acid lcsh:QD241-441 chemistry.chemical_compound Caffeic Acids ethyl ferulate lcsh:Organic chemistry Drug Discovery medicine Organic chemistry oxidative stress Physical and Theoretical Chemistry ETHYL FERULATE chemistry.chemical_classification Reactive oxygen species Chromatography NADPH oxidase Chemistry Organic Chemistry NADPH Oxidases neutrophil cosmetic product Based creams Chemistry (miscellaneous) Emulsion ferulic acid Molecular Medicine Liberation Emulsions Oxidative stress |
| Zdroj: | Molecules, Vol 19, Iss 6, Pp 8124-8139 (2014) Molecules Molecules; Volume 19; Issue 6; Pages: 8124-8139 Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1420-3049 |
| Popis: | Made available in DSpace on 2014-12-03T13:11:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-01Bitstream added on 2014-12-03T13:22:29Z : No. of bitstreams: 1 WOS000338586700074.pdf: 325510 bytes, checksum: 7b409a85b4c98d6a590e9b3663211a3d (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Ethyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid (FA), as free radical scavengers, inhibitors of oxidants produced by leukocytes and the alterations in rheological properties when incorporated in emulsion based creams. The cell-free antiradical capacity of FAEE was decreased compared to FA. However, FAEE was more effective regarding the scavenging of reactive oxygen species produced by activated leukocytes. Stress and frequency sweep tests showed that the formulations are more elastic than viscous. The viscoelastic features of the formulations were confirmed in the creep and recovery assay and showed that the FAEE formulation was less susceptive to deformation. Liberation experiments showed that the rate of FAEE release from the emulsion was slower compared to FA. In conclusion, FAEE is more effective than FA as a potential inhibitor of oxidative damage produced by oxidants generated by leukocytes. The rheological alterations caused by the addition of FAEE are indicative of lower spreadability, which could be useful for formulations used in restricted areas of the skin. Univ Estadual Paulista, UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil Univ Estadual Paulista, UNESP, Dept Cosmetol, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil Univ Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, Brazil Univ Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, Brazil Univ Estadual Paulista, UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil Univ Estadual Paulista, UNESP, Dept Cosmetol, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil Univ Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, Brazil Univ Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, Brazil |
| Databáze: | OpenAIRE |
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