Regulation of Clusterin Gene Expression
Autor: | Marilina García-Aranda, Maximino Redondo, Alfonso Serrano |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Gene isoform DNA Repair DNA repair Apoptosis Computational biology Biology Biochemistry 03 medical and health sciences Alzheimer Disease Neoplasms medicine Humans Protein Isoforms Molecular Targeted Therapy Epigenetics Molecular Biology Transcription factor Gene Clusterin Cancer Genetic Therapy Cell Biology General Medicine Cell cycle medicine.disease eye diseases 030104 developmental biology Gene Expression Regulation biology.protein sense organs Signal Transduction |
Zdroj: | Current Protein & Peptide Science. 19:612-622 |
ISSN: | 1389-2037 |
Popis: | Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discovery, numerous studies have linked clusterin expression deregulation with various physio-pathological processes such as cancer or Alzheimer's disease. Although the results of such investigations have sometimes been contradictory, mainly due to the dichotomous role of clusterin isoforms, it has been demonstrated that this protein is involved in diverse cellular processes, including apoptosis, cell cycle regulation, DNA repair or the acquisition of cell resistance against multiple conventional therapies. These results, together with the breakthrough of gene therapies, have motivated a great effort to elucidate the importance of clusterin as a potential therapeutic target. However, the understanding of a single gene, with multiple RNA transcripts and several protein isoforms has turned out to be a complex task. In this review, we summarize the studies published to date on factors that can affect clusterin expression and evaluate if a better understanding of this complex gene/protein would be useful to develop new treatment strategies for cancer and other pathologies. |
Databáze: | OpenAIRE |
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