Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: An International Multi-Institutional Analysis
| Autor: | Marc de Perrot, Prodipto Pal, Luka Brcic, Yu Zhi Zhang, Nina Chang, Yoshiaki Zaizen, Aliya N. Husain, Alberto M. Marchevsky, Andrew G. Nicholson, Anja C. Roden, Jefree J. Schulte, Richard Attanoos, David B. Chapel, Eric Santoni-Rugiu, Henry D. Tazelaar, Thomas Krausz, Heather Chen, Sara Bird Rørvig, Sonja Klebe, Kenzo Hiroshima, Leslie A. Litzky, Sanja Dacic, Birgit Weynand, Ming-Sound Tsao, Junya Fukuoka, Ann E. Walts, Kazuki Nabeshima, Juliet Burn, Jeffrey Mueller, Françoise Galateau-Sallé, Kelly J. Butnor, Theresa Maria Godschachner |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Necrosis medicine.medical_treatment Biopsy Pleural Neoplasms Resection PLEURAL MALIGNANT MESOTHELIOMA 03 medical and health sciences 0302 clinical medicine Medicine Humans Mesothelioma Nuclear grade Neoadjuvant therapy medicine.diagnostic_test business.industry Mesothelioma Malignant Histology General Medicine medicine.disease Prognosis 030104 developmental biology 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | American journal of clinical pathology. 156(6) |
| ISSN: | 1943-7722 |
| Popis: | Objectives Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy and resection specimens of pleural MM. Methods Histologic subtype, percentage of epithelioid morphology, nuclear grade, and the presence or absence of necrosis were compared in 429 paired biopsies and resection specimens of pleural MM from 19 institutions. Results Histologic subtype was concordant in 81% of cases (κ = 0.58). When compared with resection specimens, epithelioid morphology at biopsy had a positive predictive value (PPV) of 78.9% and a negative predictive value (NPV) of 93.5%; sarcomatoid morphology showed high PPV (92.9%) and NPV (99.3%), and biphasic morphology PPV was 89.7% and NPV was 79.7%. Agreement of the percentage of epithelioid morphology was fair (κ = 0.27). Nuclear grade and necrosis were concordant in 75% (κ = 0.59) and 81% (κ = 0.53) of cases, respectively. Nuclear grade showed moderate (κ = 0.53) and substantial (κ = 0.67) agreement from patients with and without neoadjuvant therapy, respectively, and necrosis showed moderate (κ = 0.47 and κ = 0.60) agreement, respectively, in the same subsets of paired specimens. Conclusions Paired biopsy-resection specimens from pleural MM show overall moderate agreement in pathologic parameters. These findings may help guide postbiopsy management and triage of patients with MM. |
| Databáze: | OpenAIRE |
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