Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis
| Autor: | Caihong Chen, Shaorong Chen, Pingping Shu, Zhuna Wu, Yumin Ke, Qirong Shi, Ruying Lin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Biophysics
Protein Serine-Threonine Kinases Biochemistry Metastasis Mice 03 medical and health sciences 0302 clinical medicine Glucosides Cell Movement Cell Line Tumor medicine Animals Humans Hippo Signaling Pathway Cell Proliferation 030304 developmental biology Mice Inbred BALB C 0303 health sciences Hippo signaling pathway Cell growth Kinase Chemistry Endometrial cancer General Medicine Endoplasmic Reticulum Stress medicine.disease Endometrial Neoplasms Hippo signaling 030220 oncology & carcinogenesis Flavanones Cancer cell Cancer research Unfolded protein response Female Scutellaria baicalensis |
| Zdroj: | Acta Biochimica et Biophysica Sinica. 51:1096-1105 |
| ISSN: | 1672-9145 |
| DOI: | 10.1093/abbs/gmz109 |
| Popis: | Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated. In this study, we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer. Firstly, we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis. Mechanistically, wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1, leading to the activation of the Hippo signaling pathway. Taken together, in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|