Mini-review: Islet transplantation to create a bioartificial pancreas

Autor:	Antonios G. Mikos, Robert C. Thomson, Maria Papadaki, Susan L. Ishaug, Stylianos Kouvroukoglou
Rok vydání:	1994
Předmět:	geography Bioartificial pancreas geography.geographical_feature_category Mechanical integrity Bioengineering Biology Islet Applied Microbiology and Biotechnology Mini review Transplantation Artificial organ Immune system Immunology Biotechnology Immune rejection
Zdroj:	Biotechnology and Bioengineering. 43:673-677
ISSN:	1097-0290 0006-3592
DOI:	10.1002/bit.260430717
Popis:	Donor scarcity precludes the use of pancreatic transplantation to treat type I diabetes. Xenogeneic islet transplantation offers the possibility of overcoming this problem; however, it entails the use of immunoisolation devices to prevent immune rejection of the transplanted islets. These devices consist of a semipermeable membrane, which surrounds the islets and isolates them from the host's immune system, while allowing the passage of insulin and essential nutrients, including glucose. Problems associated with proposed device designs include diffusion limitations, biocompatibility, device retrieval in the event of failure, and mechanical integrity. Microencapsulation appears to be the most promising system of immunoisolation, however, the design of a device suitable for human clinical use remains a challenge. (c) 1994 John Wiley & Sons, Inc.
Databáze:	OpenAIRE
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