Botulinum Toxin Injection for Treatment of Gastroparesis
| Autor: | Pankaj J. Pasricha, Trisha Pasricha |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Gastroparesis Botulinum toxin injection Placebo Gastroenterology Article Injections law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Refractory law Internal medicine medicine Humans Botulinum Toxins Type A Randomized Controlled Trials as Topic business.industry medicine.disease Pylorus Botulinum toxin Treatment Outcome medicine.anatomical_structure Neuromuscular Agents 030220 oncology & carcinogenesis Pyloric dysfunction 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Gastrointestinal Endoscopy Clinics of North America. 29:97-106 |
| ISSN: | 1052-5157 |
| Popis: | Refractory gastroparesis is among the most difficult therapeutic challenges in gastroenterology. Pyloric dysfunction has been described in a subset of patients with gastroparesis, prompting experimentation with botulinum toxin injections into the pylorus, which is relatively safe and has been successfully used in other gastrointestinal disorders. However, causality between pyloric dysfunction and symptoms of gastroparesis has never been demonstrated. Although several open-label studies showed initial promise, 2 randomized clinical trials failed to elicit a difference in clinical outcomes in botulinum toxin versus placebo. Based on current evidence, further use of botulinum toxin for gastroparesis is discouraged outside of a research trial. |
| Databáze: | OpenAIRE |
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