Modulation of IL-12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice
| Autor: | F P Leivas Leite, Carlos James Scaini, P. M. M. de Leon, Maria Elisabeth Aires Berne, M. Q. de Moura, L. F. d. C. de Avila |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Immunology law.invention 03 medical and health sciences Probiotic Interferon-gamma Mice Downregulation and upregulation law medicine Animals Innate immune system Toxocariasis biology Probiotics Toxocara canis infection Toxocara canis biology.organism_classification medicine.disease Interleukin-12 Saccharomyces boulardii 030104 developmental biology Interleukin 12 Cytokines Parasitology Female |
| Zdroj: | Parasite immunology. 38(5) |
| ISSN: | 1365-3024 |
| Popis: | In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold increase in supplemented infected mice comparing with not supplemented group. Regarding IFNγ, similar results were observed, since probiotic supplementation induced approximately 43-fold increase, but only in uninfected mice (P |
| Databáze: | OpenAIRE |
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