Subventricular zone contacting glioblastoma: tumor size, molecular biological factors and patient survival
| Autor: | Harry Pinson, Giorgio Hallaert, Tom Boterberg, D. Vanhauwaert, D. Van Roost, C. Van den Broecke, J.P. Kalala |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Oncology medicine.medical_specialty animal diseases medicine.medical_treatment Subventricular zone macromolecular substances 030218 nuclear medicine & medical imaging Biological Factors 03 medical and health sciences 0302 clinical medicine Lateral Ventricles Internal medicine Tumor Microenvironment medicine Humans Radiology Nuclear Medicine and imaging Antineoplastic Agents Alkylating DNA Modification Methylases neoplasms Retrospective Studies Hematology Tumor size Brain Neoplasms business.industry Patient survival General Medicine Prognosis medicine.disease nervous system diseases Radiation therapy DNA Repair Enzymes medicine.anatomical_structure nervous system 030220 oncology & carcinogenesis Glioblastoma business |
| Zdroj: | Acta Oncologica. 59:1474-1479 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/0284186x.2020.1794032 |
| Popis: | Several studies show that subventricular zone (SVZ) contact of glioblastoma at diagnosis is a negative prognosticator of survival. In this report, we study glioblastoma patient survival, molecular biological and MRI-based volumetric findings according to SVZ contact.We conducted a retrospective study of adult patients diagnosed with supratentorial glioblastoma and uniformly treated with temozolomide-based chemoradiotherapy after surgery. The patient cohort was dichotomized according to tumor contact with the SVZ at diagnosis as determined on preoperative MR imaging. Tumor volume was measured using semi-automated segmentation technique. MGMT-gene promoter methylation and IDH mutation status were determined on stored tumor tissue. Kaplan-Meier survival curves were constructed. Cox regression analysis was used to adjust for known confounding factors of glioblastoma patient survival.A total of 214 patients were included in the study of whom 68% belonged to the SVZThis study confirms SVZ contact at diagnosis as an independent negative prognostic factor for glioblastoma patient survival. SVZ |
| Databáze: | OpenAIRE |
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