Diffusion MRI biomarkers of white matter microstructure vary nonmonotonically with increasing cerebral amyloid deposition

Autor: Els Fieremans, Dmitry S. Novikov, Ricardo S. Osorio, Timothy M. Shepherd, Benjamin Ades-Aron, Ileana O. Jelescu, James S. Babb, James E. Galvin, Kent Friedman, Jian W. Dong
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
alzheimers association workgroups
Aging
Pathology
diagnostic guidelines
florbetapir f 18
0302 clinical medicine
Medicine
Cognitive impairment
CIBM-AIT
General Neuroscience
amyloid
Middle Aged
White matter microstructure
Diffusion Tensor Imaging
medicine.anatomical_structure
Amyloid deposition
integrity
Female
white matter
medicine.medical_specialty
Amyloid
alzheimer
brain
Article
national institute
White matter
03 medical and health sciences
mild cognitive impairment
Alzheimer Disease
Humans
Dementia
Pathological
Aged
disease
Amyloid beta-Peptides
kurtosis
business.industry
data set uds
medicine.disease
diffusion mri
white matter tract integrity
Cross-Sectional Studies
030104 developmental biology
Positron-Emission Tomography
Neurology (clinical)
Geriatrics and Gerontology
business
Biomarkers
030217 neurology & neurosurgery
dementia
Developmental Biology
Diffusion MRI
Zdroj: Neurobiol Aging
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2020.01.009
Popis: Beta amyloid (A beta) accumulation is the earliest pathological marker of Alzheimer's disease (AD), but early AD pathology also affects white matter (WM) integrity. We performed a cross-sectional study including 44 subjects (23 healthy controls and 21 mild cognitive impairment or early AD patients) who underwent simultaneous PET-MR using 18F-Florbetapir, and were categorized into 3 groups based on Ab burden: A beta- [mean mSUVr = 1.17]. Intergroup comparisons of diffusion MRI metrics revealed significant differences across multiple WM tracts. A beta i group displayed more restricted diffusion (higher fractional anisotropy, radial kurtosis, axonal water fraction, and lower radial diffusivity) than both A beta- and A beta+ groups. This nonmonotonic trend was confirmed by significant continuous correlations between mSUVr and diffusion metrics going in opposite direction for 2 cohorts: pooled A beta-/A beta i and pooled A beta i/A beta+. The transient period of increased diffusion restriction may be due to inflammation that accompanies rising A beta burden. In the later stages of A beta accumulation, neurodegeneration is the predominant factor affecting diffusion. (C) 2020 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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