Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock

Autor: Jay S. Steingrub, Sheila Willatts, Carl Arneson, José A. Lorente, Jill Donaldson, Jan Bakker, Michael S. Silverman, Robert Grover, Steven H. Grossman, Laurent Holzapfel, Jukka Takala, Desmond P. Breen, Antonio Anzueto, A McLuckie, Ángel Juan Gordo López, Michael Brockway, Geraldine Grove
Rok vydání: 2004
Předmět:
Zdroj: Critical care medicine. 32(1)
ISSN: 0090-3493
Popis: Objective: To assess the safety and efficacy of the nitric oxide synthase inhibitor 546C88 in patients with septic shock. The predefined primary efficacy objective was survival at day 28. Design: Multiple-center, randomized, two-stage, double-blind, placebo-controlled, safety and efficacy study. Setting: A total of 124 intensive care units in Europe, North America, South America, South Africa, and Australasia. Patients: A total of 797 patients with septic shock diagnosed for
Databáze: OpenAIRE