Review of Ovarian Tumors in Children and Adolescents: Radiologic-Pathologic Correlation
Autor: | Jin Woong Kim, Sang Soo Shin, Seo In Jeong, Heoung Keun Kang, Kyoung Hwa Lee, Suk Hee Heo, Woo Dae Kang, Hyo Soon Lim, Yong Yeon Jeong, Yoo Duk Choi |
---|---|
Rok vydání: | 2014 |
Předmět: |
Diagnostic Imaging
endocrine system Pathology medicine.medical_specialty Abdominal pain Adolescent endocrine system diseases Malignancy Human chorionic gonadotropin Diagnosis Differential Biomarkers Tumor medicine Humans Precocious puberty Radiology Nuclear Medicine and imaging Fertility preservation Child Tumor marker Ovarian Neoplasms medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease Female Differential diagnosis medicine.symptom business |
Zdroj: | RadioGraphics. 34:2039-2055 |
ISSN: | 1527-1323 0271-5333 |
Popis: | The incidence, histologic distribution, and clinical manifestations of ovarian tumors in the pediatric population are distinct from those in adults. Although ovarian neoplasms in childhood and adolescence are rare, the diagnosis should be considered in young girls with abdominal pain and a palpable mass. Differential diagnosis in children and adolescents with ovarian tumors should be conducted on the basis of unique clinical manifestations, elevated serum tumor marker levels, and distinctive imaging findings. Although the clinical manifestations are nonspecific and may overlap, they may assist in diagnosis of some types of ovarian tumors. Children who present with a palpable mass or symptoms of precocious puberty have a high likelihood of malignancy. Many ovarian tumors are associated with abnormal hormonal activity and/or abnormal sexual development. Elevated levels of serum tumor markers, including α-fetoprotein, the beta subunit of human chorionic gonadotropin, and CA-125, raise concern for ovarian malignancies. However, negative tumor markers do not exclude the possibility of malignancy. Identification of imaging features at ultrasonography, computed tomography, and magnetic resonance imaging can help differentiate benign from malignant ovarian tumors and, in turn, plays a crucial role in determining treatment options. At imaging, malignant ovarian tumors usually appear predominantly solid or heterogeneous and are larger than benign tumors. Because surgery is the primary treatment for ovarian tumors, ovarian salvage with fertility preservation and use of a minimally invasive surgical technique are important in children and adolescents. |
Databáze: | OpenAIRE |
Externí odkaz: |