Prevalence of endocrine disorders and their associated factors in transfusion-dependent thalassemia patients: a historical cohort study in Southern Iran
| Autor: | Asghar Bazrafshan, Omid Reza Zekavat, Sezaneh Haghpanah, Haleh Bozorgi, Mohammadreza Bordbar, Forough Saki, Mehran Karimi |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Thalassemia medicine.medical_treatment Splenectomy Thyrotropin 030209 endocrinology & metabolism Iran Endocrine System Diseases Young Adult 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Endocrinology Bone Density Risk Factors Diabetes mellitus Prevalence medicine Vitamin D and neurology Humans Endocrine system Risk factor Child business.industry Phosphorus Middle Aged medicine.disease Thyroxine Hypoparathyroidism Parathyroid Hormone 030220 oncology & carcinogenesis Ferritins Quality of Life Calcium Female business Body mass index |
| Zdroj: | Journal of Endocrinological Investigation. 42:1467-1476 |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-019-01072-z |
| Popis: | Transfusion-dependent beta-thalassemia (TDT) patients suffer from various endocrinopathies. The main contributing factor associated with these complications is iron overload, secondary to frequent blood transfusions. To improve patients’ quality of life, we evaluated the prevalence of endocrine disorders while considering the associated factors for further assessment. Seven hundred thirteen transfusion-dependent thalassemia patients with age range 10–62 years were enrolled in this study. Serum calcium, phosphorous, fast blood sugar, ferritin, 25-OH vitamin D, free thyroxin, thyroid-stimulating hormone and parathyroid hormone were assessed. Bone mineral density was measured by dual-energy X-ray absorptiometry. In total, 86.8% of the TDT patients suffered from at least one endocrinopathy. The prevalence of endocrinopathies in descending order of frequency was low bone mass (72.6%), hypogonadism (44.5%), diabetes mellitus (15.9%), hypoparathyroidism (13.2%), and hypothyroidism (10.7%). Age, body mass index and splenectomy were significantly associated with most of the endocrine disorders. Endocrine complications are frequently observed in TDT patients. Splenectomy is a major risk factor and should be generally avoided unless it is highly indicated. Periodic surveillance of endocrine function and proper management of iron overload are advised. |
| Databáze: | OpenAIRE |
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