Fur is required for the activation of virulence gene expression through the induction of the sae regulatory system in Staphylococcus aureus
| Autor: | Julie A. Morrissey, Brian J. Wilkinson, Arunachalam Muthaiyan, Emma Tarrant, Mrittika Sengupta, Joanne Purves, Robert Stephenson, Nagender Ledala, Alan Cockayne, Miranda Johnson, Peter H. Williams, Radheshyam K. Jayaswal |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Staphylococcus aureus Virulence Factors Iron Virulence Repressor Biology medicine.disease_cause Microbiology Article Bacterial Proteins parasitic diseases Extracellular medicine Transcription factor Regulation of gene expression integumentary system Gene Expression Profiling Hemolysin Gene Expression Regulation Bacterial General Medicine Repressor Proteins Gene expression profiling Infectious Diseases bacteria Protein Kinases Transcription Factors |
| Zdroj: | International Journal of Medical Microbiology. 301:44-52 |
| ISSN: | 1438-4221 |
| DOI: | 10.1016/j.ijmm.2010.05.003 |
| Popis: | Our previous studies showed that both Sae and Fur are required for the induction of eap and emp expression in low iron. In this study, we show that expression of sae is also iron-regulated, as sae expression is activated by Fur in low iron. We also demonstrate that both Fur and Sae are required for full induction of the oxidative stress response and expression of non-covalently bound surface proteins in low-iron growth conditions. In addition, Sae is required for the induced expression of the important virulence factors isdA and isdB in low iron. Our studies also indicate that Fur is required for the induced expression of the global regulators Agr and Rot in low iron and a number of extracellular virulence factors such as the haemolysins which are also Sae- and Agr-regulated. Hence, we show that Fur is central to a complex regulatory network that is required for the induced expression of a number of important S. aureus virulence determinants in low iron. |
| Databáze: | OpenAIRE |
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