The role of transcription factor caudal-related homeobox transcription factor 2 in colorectal cancer
| Autor: | Chia-Chou Yeh, Hsien-Bing Huang, Chin-Chia Wu, Ta-Wen Hsu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer biomarker
business.industry Colorectal cancer Review Article General Medicine medicine.disease Intestinal epithelium digestive system diseases Caudal-related homeobox transcription factor 2 03 medical and health sciences 0302 clinical medicine Potential biomarkers embryonic structures Cancer research Medicine Immunohistochemistry Homeobox 030212 general & internal medicine Personalized medicine CDX2 business Transcription factor 030217 neurology & neurosurgery |
| Zdroj: | Tzu-Chi Medical Journal |
| ISSN: | 1016-3190 |
| DOI: | 10.4103/tcmj.tcmj_49_20 |
| Popis: | Colorectal cancer (CRC) is one of the most malignant tumors in humans and causes mass mortality. In the age of precise medicine, more and more subtypes of CRC were classified. The caudal-related homeobox transcription factor 2 (CDX2) is an intestine-specific transcription factor which is implicated in differentiation, proliferation, cell-adhesion, and migration. The loss of CDX2 in immunohistochemical stain was reported to be a prognostic factor of colon cancer, but the clinical application remained controversial. Most of the CRCs expressed or over-expressed CDX2. Homeobox genes can display either an oncogenic or a tumor-suppressing activity. CDX2 regulates the developing intestinal epithelium and CRC by different pathways. The complex regulation of CDX2 and its complex targets cause the difficulties of application for CDX2 in the prediction of prognosis. However, CDX2 is a potential biomarker applied in the precise classification of CRC for personalized medicine. This review partially clarifies the role of CDX2 in CRC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|