Are individuals with lower neutrophil oxidative burst activity more prone to Helicobacter pylori infection?
| Autor: | Yu Fukuoka, Ippei Takahashi, Tadashi Shimoyama, Makoto Yaegaki, Masashi Matsuzaka, Kiyonori Yamai, Takashi Umeda, Shinsaku Fukuda, Shigeyuki Nakaji, Ryousuke Tsuya, Juichi Sakamoto |
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| Rok vydání: | 2008 |
| Předmět: |
Helicobacter pylori infection
Neutrophils Biophysics macromolecular substances Helicobacter Infections Gastric mucosa medicine Humans Neutrophil oxidative burst Respiratory Burst biology Helicobacter pylori bacterial infections and mycoses biology.organism_classification Antibodies Bacterial Peripheral blood Respiratory burst Blood Cell Count Titer medicine.anatomical_structure Chemistry (miscellaneous) Immunology biology.protein Disease Susceptibility Antibody |
| Zdroj: | Luminescence : the journal of biological and chemical luminescence. 23(3) |
| ISSN: | 1522-7243 |
| Popis: | Helicobacter pylori infection has been reported to cause enhanced reactive oxygen species in the gastric mucosa. We examined the relationship between H. pylori infection and neutrophil function of peripheral blood. The subjects were 904 volunteers who participated in the Iwaki Health Promotion Project in 2005. 158 subjects who were infected with H. pylori in 2005 also participated in this project in 2006 and were categorized into two groups: the eradication group, in which H. pylori was successfully eradicated during the 12 month period, and the non-eradication group, in which eradication was unsuccessful or the subjects did not receive eradication therapy. The laboratory assays performed were: a titre of H. pylori antibody; neutrophil counts; and oxidative burst activity (OBA) of neutrophils. Logistic regression analysis was executed, with H. pylori infection as the dependent variable and other items as the independent variables. OBA showed an inverse association with H. pylori infection in 2005. Additionally, when comparing the eradication and non-eradication groups, the change rates of OBA between 2005 and 2006 did not show any significant difference. It was concluded that H. pylori infection does not lower OBA, but those individuals in whom OBA was lower were more prone to H. pylori infection. |
| Databáze: | OpenAIRE |
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