An introduction to free radical biochemistry
| Autor: | K. H. Cheeseman, T. F. Slater |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Antioxidant Free Radicals Superoxide Cells Radical medicine.medical_treatment Hydrogen Peroxide General Medicine chemistry.chemical_compound Unpaired electron chemistry Biochemistry Superoxides medicine Animals Humans Disease Hydroxyl radical Reactive Oxygen Species Hydrogen peroxide Free Radical Formation |
| Zdroj: | British Medical Bulletin. 49:481-493 |
| ISSN: | 1471-8391 0007-1420 |
| DOI: | 10.1093/oxfordjournals.bmb.a072625 |
| Popis: | Free radicals are chemical species possessing an unpaired electron that can be considered as fragments of molecules and which are generally very reactive. They are produced continuously in cells either as accidental by-products of metabolism or deliberately during, for example, phagocytosis. The most important reactants in free radical biochemistry in aerobic cells are oxygen and its radical derivatives (superoxide and hydroxyl radical), hydrogen peroxide and transition metals. Cells have developed a comprehensive array of antioxidant defences to prevent free radical formation or limit their damaging effects. These include enzymes to decompose peroxides, proteins to sequester transition metals and a range of compounds to 'scavenge' free radicals. Reactive free radicals formed within cells can oxidise biomolecules and lead to cell death and tissue injury. Establishing the involvement of free radicals in the pathogenesis of a disease is extremely difficult due to the short lifetimes of these species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|