Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis
| Autor: | Edit Nagy, Charles Brink, Athanase Benetos, Kathy Bean, Magnus Bäck, C. Labat, Mohamed Temmar |
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| Přispěvatelé: | Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Telomere Cardiodology Center, University of Ghardaia, Department of Cardiology, Karolinska University Hospital, Karolinska Institutet [Stockholm], Department of Medicine [Karolinska Institute], Karolinska University Hospital [Stockholm], Centre Investigations Préventives et Cliniques (IPC), CPAM, Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Saliva Physiology Blood Pressure Disease 030204 cardiovascular system & hematology Carotid Intima-Media Thickness MESH: Hypertension MESH: Vascular Stiffness MESH: Atherosclerosis 0302 clinical medicine Waist–hip ratio MESH: Risk Factors Risk Factors Subclinical infection MESH: Aged Metabolic Syndrome MESH: Pulse Wave Analysis 0303 health sciences MESH: Middle Aged MESH: Waist-Hip Ratio leukotriene MESH: Dinoprostone MESH: Blood Pressure Middle Aged 3. Good health Matrix Metalloproteinase 9 Cardiovascular Diseases Creatinine Hypertension Female MESH: Carotid Intima-Media Thickness medicine.symptom Inflammation Mediators Cardiology and Cardiovascular Medicine medicine.medical_specialty MESH: Metabolic Syndrome pulse wave velocity MESH: Inflammation Mediators Inflammation MESH: Creatinine Pulse Wave Analysis Leukotriene B4 Dinoprostone C-reactive protein 03 medical and health sciences ORIGINAL PAPERS: Blood vessels Vascular Stiffness [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Internal medicine MESH: C-Reactive Protein Internal Medicine medicine Humans MESH: Saliva 030304 developmental biology Aged MESH: Humans business.industry Waist-Hip Ratio MESH: Cardiovascular Diseases MESH: Matrix Metalloproteinase 9 MESH: Leukotriene B4 medicine.disease Atherosclerosis MESH: Male Blood pressure Endocrinology inflammation MESH: Muramidase Immunology MESH: Biomarkers Arterial stiffness Muramidase Metabolic syndrome business MESH: Female Biomarkers |
| Zdroj: | Journal of Hypertension Journal of Hypertension, Lippincott, Williams & Wilkins, 2013, 31 (11), pp.2251-2258. ⟨10.1097/HJH.0b013e328363dccc⟩ |
| ISSN: | 1473-5598 0263-6352 |
| DOI: | 10.1097/HJH.0b013e328363dccc⟩ |
| Popis: | International audience; OBJECTIVE:Whereas circulating levels of C-reactive protein (CRP) have been associated with, for example, arterial stiffness, subclinical atherosclerosis and metabolic syndrome, other inflammatory biomarkers with potential interest for these conditions may not be measurable systemically. The predictive value of salivary biomarkers in these contexts has remained largely unexplored. The aim of the present study was to establish the association of different salivary biomarkers of inflammation with subclinical cardiovascular disease.METHODS:Two hundred and fifty-nine individuals were included in the study. Saliva and plasma samples were collected, and each individual underwent carotid ultrasound and measures of pulse wave velocity and blood pressure. Medical history of previous cardiovascular disease, current medications and smoking were collected by questionnaire.RESULTS:Salivary levels of CRP, leukotriene B4 (LTB4), prostaglandin E2 (PGE2), matrix metalloproteinase 9 (MMP-9), creatinine and lysozyme were measured. Salivary levels of CRP were significantly correlated with plasma levels (r = 0.73, P |
| Databáze: | OpenAIRE |
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