Muscle-derived factors influencing bone metabolism
| Autor: | Jonathan W. Lowery, Benjamin P. Leeds, Victoria S. Zysik, Tyler K. Jobe, Kevin J. Gries, Nicole Griffin |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Skeletal muscle Cell Biology Stimulus (physiology) Biology Bone health Bone and Bones Resorption Bone remodeling Cytokine medicine.anatomical_structure Endocrinology Internal medicine Myokine medicine Cytokines Muscle Skeletal Exercise Function (biology) Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology. 123:57-63 |
| ISSN: | 1084-9521 |
| Popis: | A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated by a given stimulus, such as exercise, aging, and inactivity. Moreover, emerging evidence indicates that bone is heavily influenced by soluble factors derived from skeletal muscle (i.e., muscle-to-bone communication). The purpose of this review is to discuss the regulation of bone remodeling (formation and/or resorption) through skeletal muscle-derived cytokines (hereafter myokines) including the anti-inflammatory cytokine METRNL and pro-inflammatory cytokines (e.g., TNF-α, IL-6, FGF-2 and others). Our goal is to highlight possible therapeutic opportunities to improve muscle and bone health in aging. |
| Databáze: | OpenAIRE |
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