Total Body Retention of Orally Administered47Calcium in Primary Hyperparathyroidism
| Autor: | Stephen J. Marx, L. P. Georges, L. E. Mallette, J. E. Sode, Gerald D. Aurbach |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Sarcoidosis endocrine system diseases Endocrinology Diabetes and Metabolism Idiopathic hypercalciuria Parathyroid Diseases Clinical Biochemistry Administration Oral chemistry.chemical_element Calcium Disorders of calcium metabolism Biochemistry Endocrinology Oral administration Internal medicine medicine Humans Hypophosphatemia Familial Aged Hyperparathyroidism Hyperplasia Calcium Radioisotopes Multiple Endocrine Neoplasia Biochemistry (medical) Total body Middle Aged medicine.disease Diet Parathyroid Neoplasms chemistry Osteoporosis Female Whole body Primary hyperparathyroidism |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 40:582-588 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-40-4-582 |
| Popis: | Using a whole body radiation detector, we have measured the total body retention of 47-Ca 7 days after oral administration of the isotope to patients with various disorders of calcium metabolism. The percent retention of 47-Ca given with 90 mg of unlabeled (carrier) calcium varied with the calcium metabolic status as follows: normals (n equals 14), 33-43 percent (mean 38); primary hyperparathyroidism (n equals 28), 32-74 percent (mean 52); idiopathic hypercalciuria (n equals 9), 34-49 percent (mean 42); and hypercalcemia of other etiology (n equals 3), 23-26 percent (mean 25). Almost half (13/28) of those with hyperparathyroidism showed a retention above 55 percent, distinguishing them from subjects with idiopathic hypercalciuria. Retention of 47-Ca correlated poorly with clinical measures of severity of hyperparathyroidism. When isotope was diluted with a smaller amount of carrier calcium (20 mg), retention was increaseed in normals (n equals 5) to 46-54 percent (mean 50) and in hyperparathyroidism (n equals 5) to 64-87 percent (mean 73). After surgical cure of hyperparathyroidism retention of isotope returned toward normal in 5 of 7 subjects. Whole body retention of orally administered 47-Ca may prove useful in detecting hyperparathyroidism in subjects with mild hypercalcemia or hypercalciuria. |
| Databáze: | OpenAIRE |
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