Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy
| Autor: | Ayako Kaitani, Masato Kubo, Yoshimichi Okayama, Jiro Kitaura, Yukari Saito, Shizuo Akira, Sayuri Murasaki, Miho Nakamura, Takao Takahashi, Masahiro Kiuchi, Toshinori Nakayama, Kumiko Fujisawa, Kiyoshi Hirahara, Shota Toyoshima, Yosuke Kurashima, Kaoru Shimada, Kumi Izawa, Fujimi Arai, Naoki Takemura, Satoshi Uematsu, Jun Kunisawa, Yoshihiro Takasato, Hiroshi Kiyono |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Allergy Oral immunotherapy medicine.medical_treatment Immunology Administration Oral Cell Communication T-Lymphocytes Regulatory Treg cell Article Cell Degranulation Immunomodulation Mice 03 medical and health sciences 0302 clinical medicine Food allergy Immune Tolerance Animals Immunology and Allergy Medicine Mast Cells Desensitization (medicine) Mice Inbred BALB C business.industry Allergens medicine.disease Disease Models Animal 030104 developmental biology Desensitization Immunologic Murine model Female business Food Hypersensitivity 030215 immunology |
| Zdroj: | Mucosal Immunology |
| ISSN: | 1933-0219 |
| Popis: | Oral immunotherapy (OIT) is an effective approach to controlling food allergy. Although the detailed molecular and cellular mechanisms of OIT are unknown currently, they must be understood to advance the treatment of allergic diseases in general. To elucidate the mechanisms of OIT, especially during the immunological transition from desensitization to allergy regulation, we generated a clinical OIT murine model and used it to examine immunological events of OIT. We found that in mice that completed OIT successfully, desensitized mast cells (MCs) showed functionally beneficial alterations, such as increased induction of regulatory cytokines and enhanced expansion of regulatory T cells. Importantly, these regulatory-T-cell-mediated inhibitions of allergic responses were dramatically decreased in mice lacking OIT-induced desensitized MC. Collectively, these findings show that the desensitization process modulates the activation of MCs, leading directly to enhanced induction of regulatory-T-cell expansion and promotion of clinical allergic unresponsiveness. Our results suggest that efficiently inducing regulatory MCs is a novel strategy for the treatment of allergic disease. |
| Databáze: | OpenAIRE |
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