Screening for abnormal vaginal microflora by self-assessed vaginal pH does not enable detection of sexually transmitted infections in Ugandan women
| Autor: | Francesca Donders, Gert Bellen, John Lule, T Michiels, Gilbert G.G. Donders, Christophe E. Depuydt, Jacobat Byamughisa, Natalie Eggermont |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Sexually Transmitted Diseases Atopobium vaginae Self Administration Mycoplasma hominis medicine.disease_cause urologic and male genital diseases Specimen Handling 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Mass Screening Uganda 030212 general & internal medicine Biology Mass screening Vaginitis Gynecology 030219 obstetrics & reproductive medicine biology business.industry General Medicine Hydrogen-Ion Concentration biology.organism_classification medicine.disease female genital diseases and pregnancy complications Infectious Diseases medicine.anatomical_structure Vagina Dysbiosis Trichomonas vaginalis Female Human medicine Bacterial vaginosis Chlamydia trachomatis business |
| Zdroj: | Diagnostic microbiology and infectious disease |
| ISSN: | 0732-8893 |
| Popis: | Objective: Is self-assessed vaginal pH measurement to detect abnormal vaginal bacterial microflora (AVF) an adequate prescreening method for detection of genital sexually transmitted infections (STIs)? Materials and methods: A total of 360 Ugandan women tested themselves with a gloved finger and a pH color strip. PCR for bacterial vaginosis (BV)-associated bacteria was tested by PCR for Mycoplasma hominis, Ureaplasma urealyticum, and/or Atopobium vaginae, while the STIs were diagnosed by positive PCR for Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and/or Trichomonas vaginalis. Results: A strong correlation was found between self-assessed pH values and BV-associated bacteria (P < 0.0001), but not with STIs, not as single infections, nor in general. Conclusion: Self-measured vaginal pH correlated well with markers of high-risk microflora types such as BV or aerobic vaginitis, but not with STIs. Hence, in a screening program addressing AVF in low-resource countries, extra specific tests are required to exclude STIs. (C) 2015 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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