Periconceptional nonsteroidal anti‐inflammatory drug use, folic acid intake, and the risk of spina bifida
| Autor: | Allen A. Mitchell, Daina B. Esposito, Samantha E. Parker, Martha M. Werler, Sarah C. Tinker |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Embryology medicine.medical_specialty Naproxen Health Toxicology and Mutagenesis Toxicology Article Folic Acid Pregnancy Epidemiology medicine Humans Spinal Dysraphism Aspirin business.industry Spina bifida Obstetrics Anti-Inflammatory Agents Non-Steroidal Infant Odds ratio medicine.disease Ibuprofen Confidence interval Pharmaceutical Preparations Case-Control Studies Pediatrics Perinatology and Child Health Female business Developmental Biology medicine.drug |
| Zdroj: | Birth Defects Res |
| ISSN: | 2472-1727 |
| Popis: | BACKGROUND: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy may increase risk for neural tube defects (NTDs), including spina bifida. Folic acid intake can prevent NTDs, but it is not known whether it modifies any risks associated with NSAID use. OBJECTIVES: To assess the impact of periconceptional NSAID use on the risk of spina bifida overall and stratified by folic acid intake. STUDY DESIGN: We analyzed 1998–2015 data from the Slone Epidemiology Center Birth Defects Study, a multi-site, case–control study. Mothers were interviewed to identify sociodemographic factors, behaviors, and exposures during pregnancy. Periconceptional NSAID use was defined as use of aspirin, ibuprofen, naproxen, or COX2 inhibitors within the month before or after the last menstrual period. Logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for NSAID use, adjusted for study center and race/ethnicity stratified by average daily folic acid intake above (“high FA”) or below (“low FA”) 400 mcg/day. RESULTS: We compared mothers of 267 infants with spina bifida to mothers of 6,233 nonmalformed controls. Among control mothers, 20% used NSAIDS periconceptionally (16% ibuprofen, 4% aspirin, 3% naproxen, and |
| Databáze: | OpenAIRE |
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