5-Hydroxymethyl-oxazolidin-2-one antibacterials
| Autor: | Leyla H. Sharaf, Oludotun A. Phillips |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
DNA Topoisomerase IV
Pharmacology biology medicine.drug_class Chemistry Stereochemistry Antibiotics Dual mode General Medicine Quinolones Gram-Positive Bacteria biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents Patents as Topic chemistry.chemical_compound Bacterial Proteins Gram-Negative Bacteria Drug Discovery medicine Humans Hydroxymethyl Oxazolidinones Bacteria |
| Zdroj: | Expert Opinion on Therapeutic Patents. 19:529-540 |
| ISSN: | 1744-7674 1354-3776 |
| DOI: | 10.1517/17530050902800142 |
| Popis: | The application, WO2008062379, claims chimeric compounds comprising chemically linked 5-hydroxymethyl-oxazolidinone and tetracyclic-quinolone moieties. The claimed compounds are potent expanded-range antibacterial agents against selected gram-positive and gram-negative bacteria, which may exhibit dual mode of action as inhibitors of topoisomarases IV and protein synthesis. The structures of the compounds suggest that the linkers are chemically and biochemically stable. This application represents part of recently initiated research efforts at Actelion. |
| Databáze: | OpenAIRE |
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