Maintenance or Discontinuation of Antidepressants in Primary Care
| Autor: | Faye Bacon, Larisa Duffy, Caroline S Clarke, Glyn Lewis, Irwin Nazareth, Gemma Lewis, Anna Hunt, David Kessler, Paul Lanham, Alison Burns, Michael Moore, Sally Brabyn, Tony Kendrick, Michael King, Dee Mangin, Simon Gilbody, Molly Bird, Nick Freemantle, Nicola Wiles, Rachael Hunter, Louise Marston, Jodi Pervin |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Mirtazapine Kaplan-Meier Estimate Citalopram Placebo Maintenance Chemotherapy Double-Blind Method Recurrence Internal medicine Surveys and Questionnaires medicine Humans Depression (differential diagnoses) Aged Fluoxetine Sertraline Depressive Disorder Primary Health Care business.industry Hazard ratio General Medicine Middle Aged Anxiety Disorders Antidepressive Agents United Kingdom Discontinuation Withholding Treatment Female business Selective Serotonin Reuptake Inhibitors medicine.drug Follow-Up Studies |
| Zdroj: | Lewis, G, Marston, L, Duffy, L, Freemantle, N, Gilbody, S, Hunter, R, Kendrick, T, Kessler, D S, Mangin, D, King, M, Lanham, P, Moore, M, Nazareth, I, Wiles, N J, Bacon, F, Bird, M, Brabyn, S, Burns, A J, Clarke, C S, Hunt, A, Pervin, J & Lewis, G 2021, ' Maintenance or Discontinuation of Antidepressants in Primary Care ', New England Journal of Medicine, vol. 385, pp. 1257-1267 . https://doi.org/10.1056/NEJMoa2106356 |
| ISSN: | 1533-4406 1596-9819 |
| Popis: | BACKGROUNDPatients with depression who are treated in primary care practices may receive antidepressants for prolonged periods. Data are limited on the effects of maintaining or discontinuing antidepressant therapy in this setting.METHODSWe conducted a randomized, double-blind trial involving adults who were being treated in 150 general practices in the United Kingdom. All the patients had a history of at least two depressive episodes or had been taking antidepressants for 2 years or longer and felt well enough to consider stopping antidepressants. Patients who had received citalopram, fluoxetine, sertraline, or mirtazapine were randomly assigned in a 1:1 ratio to maintain their current antidepressant therapy (maintenance group) or to taper and discontinue such therapy with the use of matching placebo (discontinuation group). The primary outcome was the first relapse of depression during the 52-week trial period, as evaluated in a time-to-event analysis. Secondary outcomes were depressive and anxiety symptoms, physical and withdrawal symptoms, quality of life, time to stopping an antidepressant or placebo, and global mood ratings.RESULTSA total of 1466 patients underwent screening. Of these patients, 478 were enrolled in the trial (238 in the maintenance group and 240 in the discontinuation group). The average age of the patients was 54 years; 73% were women. Adherence to the trial assignment was 70% in the maintenance group and 52% in the discontinuation group. By 52 weeks, relapse occurred in 92 of 238 patients (39%) in the maintenance group and in 135 of 240 (56%) in the discontinuation group (hazard ratio, 2.06; 95% confidence interval, 1.56 to 2.70; PCONCLUSIONSAmong patients in primary care practices who felt well enough to discontinue antidepressant therapy, those who were assigned to stop their medication had a higher risk of relapse of depression by 52 weeks than those who were assigned to maintain their current therapy. (Funded by the National Institute for Health Research; ANTLER ISRCTN number, ISRCTN15969819. opens in new tab.) |
| Databáze: | OpenAIRE |
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