The impact of tobacco smoking on survival of patients with oral squamous cell carcinoma: a population-based retrospective study

Autor: Amanda Oester Andersen, Jakob Schmidt Jensen, Kathrine Kronberg Jakobsen, Helene Stampe, Kristoffer Juul Nielsen, Irene Wessel, Anders Christensen, Elo Andersen, Jeppe Friborg, Christian Grønhøj, Christian von Buchwald
Rok vydání: 2022
Předmět:
Zdroj: Acta Oncologica. 61:449-458
ISSN: 1651-226X
0284-186X
Popis: This article aims to evaluate the impact of smoking status, accumulated tobacco exposure (ATE), and smoking cessation on overall- and disease-free survival (OS and DFS) of patients with oral squamous cell carcinoma (OSCC).Patients with primary OSCC treated with curative intent between 2000 and 2019 in Copenhagen were included (We included 1717 patients with known smoking status (62.8% males, median age: 64 years (IQR: 57-71 years)), who had a 5-year OS of 53.7% (95%CI: 49.8%-57.9%). Based on fully adjusted multivariable Cox regression analyses, significantly elevated hazard ratios (HRs) for OS and DFS were identified for current, but not former smokers, compared to never-smokers. An approximately linear relationship between continuous ATE and survival estimates was identified. ATE analyzed as a categorical variable showed significantly elevated HRs for OS of patients with all categories (0Tobacco smoking (assessed as smoking status and ATE) was associated with inferior survival (OS and DFS) among patients with OSCC. Unfavorable long-term prognosis was significant for patients who continued smoking compared to patients with smoking cessation at diagnosis. The impact of ATE on survival of patients with OSCC may depend on the tumor subsite and/or alcohol consumption.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje