Histologic subtype of treatment failures after noninvasive therapy for superficial basal cell carcinoma: An observational study

Autor: Klara Mosterd, Aimee H.M.M. Arits, Lieke C.J. van Delft, Myrurgia Abdul Hamid, Patty J. Nelemans, Maud H.E. Jansen, Nicole W.J. Kelleners-Smeets, Marieke H. Roozeboom
Přispěvatelé: Promovendi ODB, MUMC+: MA AIOS Dermatologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Dermatologie, MUMC+: MA Dermatologie (9), MUMC+: DA Pat Pathologie (9), RS: GROW - R2 - Basic and Translational Cancer Biology
Rok vydání: 2018
Předmět:
Male
sampling error
Skin Neoplasms
Imiquimod
Gastroenterology
law.invention
030207 dermatology & venereal diseases
PHOTODYNAMIC THERAPY
0302 clinical medicine
Randomized controlled trial
law
TOPICAL IMIQUIMOD
5-fluorouracil
Treatment Failure
PUNCH BIOPSY
Photosensitizing Agents
MAL-PDT
misclassification
Middle Aged
Primary tumor
030220 oncology & carcinogenesis
NON-INFERIORITY
Female
Fluorouracil
noninvasive therapy
medicine.drug
medicine.medical_specialty
Antimetabolites
Antineoplastic
Antineoplastic Agents
Dermatology
EUROPEAN GUIDELINES
Equivalence Trials as Topic
IMIQUIMOD 5-PERCENT CREAM
SINGLE-BLIND
Superficial basal cell carcinoma
histologic subtype
03 medical and health sciences
basal cell carcinoma
Internal medicine
medicine
Humans
In patient
Basal cell carcinoma
DIAGNOSTIC-ACCURACY
CONFOCAL MICROSCOPY
Aged
business.industry
transformation
Aminolevulinic Acid
medicine.disease
SURGICAL EXCISION
superficial
Photochemotherapy
Carcinoma
Basal Cell
Observational study
Single blind
business
Zdroj: Journal of the American Academy of Dermatology, 80(4), 1022-1028. MOSBY-ELSEVIER
ISSN: 1097-6787
0190-9622
Popis: Background: There have been concerns that recurrences after noninvasive therapy for basal cell carcinoma (BCC) transform into a "more aggressive'' histologic subtype.Objective: We sought to evaluate the proportion of patients with a nonsuperficial treatment failure after noninvasive therapy for superficial BCC.Methods: An observational study was performed using data from a single blind, noninferiority, randomized controlled trial (March 2008-August 2010) with 5-year follow-up in patients with primary superficial BCC treated with methylaminolevulinate-photodynamic therapy, 5-fluorouracil, or imiquimod. Data were used from 166 adults with a histologically confirmed treatment failure.Results: A nonsuperficial subtype was found in 64 of 166 treatment failures (38.6%). Proportions with a more aggressive subtype than the primary tumor were 51.3% (38/74) for early and 28.3% (26/92) for later treatment failures (P = .003). The proportion of more aggressive early failures was significantly lower after imiquimod (26.3%) compared with methylaminolevulinate-photodynamic therapy (54.8%, P = .086) and 5-fluorouracil (66.7%, P = .011).Limitations: There was limited information on the exact time of occurrence of treatment failures.Conclusion: More aggressive treatment failure recurrences after noninvasive therapy for superficial BCC occur most often within the first 3 months posttreatment, probably indicating underdiagnosis of more aggressive components in the primary tumor rather than transformation.
Databáze: OpenAIRE
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