Polygenic control of susceptibility to murine systemic lupus erythematosus
| Autor: | Edward K. Wakeland, Jeffrey A. Longmate, Ulrich H. Rudofsky, Laurence Morel, Joel Schiffenbauer |
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| Rok vydání: | 1994 |
| Předmět: |
Genetic Markers
Male Candidate gene Heterozygote Genetic Linkage Immunology Molecular Sequence Data Mice Inbred Strains Biology Loss of heterozygosity Mice Inbred strain immune system diseases Genetic linkage medicine Immunology and Allergy Animals Humans Lupus Erythematosus Systemic Allele skin and connective tissue diseases Crosses Genetic DNA Primers Genetics Lupus erythematosus Base Sequence H-2 Antigens Chromosome Mapping Heterozygote advantage medicine.disease Lupus Nephritis Mice Inbred C57BL Infectious Diseases Phenotype Genetic marker Antibodies Antinuclear Female |
| Zdroj: | Immunity. 1(3) |
| ISSN: | 1074-7613 |
| Popis: | Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system. |
| Databáze: | OpenAIRE |
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