Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus

Autor: Yu-Ming Kang, Xiao-Yan Fan, Kai-Li Liu, Wen-Sheng Chen, Yan Zhang, Lin-Lin Jia, Hong-Li Gao, Xiao-Lian Shi, Wei Cui, Xiao-Jing Yu, Guo-Qing Zhu, Jin-Jun Liu
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Mean arterial pressure
Glutamic Acid
Peptidyl-Dipeptidase A
030204 cardiovascular system & hematology
medicine.disease_cause
Losartan
Receptor
Angiotensin
Type 1
Article
Renovascular hypertension
Rats
Sprague-Dawley
Renin-Angiotensin System
03 medical and health sciences
0302 clinical medicine
Physical Conditioning
Animal
Internal medicine
Renin–angiotensin system
medicine
Animals
Multidisciplinary
Superoxide Dismutase
business.industry
Glutamate receptor
NADPH Oxidases
medicine.disease
Angiotensin II
Rats
Dizocilpine
Disease Models
Animal
Hypertension
Renovascular
Endocrinology
Gene Expression Regulation
Receptors
Glutamate
NADPH Oxidase 2
Dizocilpine Maleate
Sedentary Behavior
Reactive Oxygen Species
business
Angiotensin II Type 1 Receptor Blockers
Excitatory Amino Acid Antagonists
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Oxidative stress
Paraventricular Hypothalamic Nucleus
Signal Transduction
medicine.drug
Zdroj: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/srep37467
Popis: Exercise training (ExT) has been reported to benefit hypertension; however, the exact mechanisms involved are unclear. We hypothesized that ExT attenuates hypertension, in part, through the renin-angiotensin system (RAS), reactive oxygen species (ROS), and glutamate in the paraventricular nucleus (PVN). Two-kidney, one-clip (2K1C) renovascular hypertensive rats were assigned to sedentary (Sed) or treadmill running groups for eight weeks. Dizocilpine (MK801), a glutamate receptor blocker, or losartan (Los), an angiotensin II type1 receptor (AT1-R) blocker, were microinjected into the PVN at the end of the experiment. We found that 2K1C rats had higher mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA). These rats also had excessive oxidative stress and overactivated RAS in PVN. Eight weeks of ExT significantly decreased MAP and RSNA in 2K1C hypertensive rats. ExT inhibited angiotensin-converting enzyme (ACE), AT1-R, and glutamate in the PVN, and angiotensin II (ANG II) in the plasma. Moreover, ExT attenuated ROS by augmenting copper/zinc superoxide dismutase (Cu/Zn-SOD) and decreasing p47phox and gp91phox in the PVN. MK801or Los significantly decreased blood pressure in rats. Together, these findings suggest that the beneficial effects of ExT on renovascular hypertension may be, in part, through the RAS-ROS-glutamate pathway in the PVN.
Databáze: OpenAIRE
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