Uremic toxin concentrations are related to residual kidney function in the pediatric hemodialysis population

Autor: Wim Van Biesen, Charlotte Samaille, Karolis Azukaitis, Ann Raes, Claus Peter Schmitt, Maria Van Dyck, Koen Van Hoeck, Brankica Spasojevic, Franz Schaefer, Griet Glorieux, Constantinos J. Stefanidis, Sunny Eloot, Michel Fischbach, Raymond Vanholder, Lukasz Obrycki, Els Holvoet, Johan Vande Walle, Saoussen Krid, Fabio Paglialonga, Varvara Askiti, Mieczysław Litwin, Nathalie Godefroid, Evelien Snauwaert, Sanne Roels, Aysun Karabay Bayazit, Bruno Ranchin, Laure Collard, Nur Canpolat, Rukshana Shroff
Přispěvatelé: Çukurova Üniversitesi, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de pédiatrie générale
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Health
Toxicology and Mutagenesis
medicine.medical_treatment
uremic toxins
030232 urology & nephrology
lcsh:Medicine
CHILDREN
Toxicology
Kidney
SERUM
chemistry.chemical_compound
0302 clinical medicine
residual kidney function
CONCENTRATIONS
Chronic kidney disease
end-stage kidney disease
Medicine and Health Sciences
Child
PERITONEAL-DIALYSIS
RISK
0303 health sciences
education.field_of_study
child
hemodialysis
Pharmacology. Therapy
End-stage kidney disease
Hemodialysis
Residual kidney function
Uremic toxins
3. Good health
Child
Preschool
Female
Glucuronide
Protein Binding
medicine.medical_specialty
RENAL-FUNCTION
Adolescent
Population
Renal function
Article
Peritoneal dialysis
03 medical and health sciences
PROTEIN-BOUND SOLUTES
Renal Dialysis
Internal medicine
medicine
Humans
INDOXYL SULFATE
Renal Insufficiency
Chronic
education
030304 developmental biology
Toxins
Biological
Uremia
ACCUMULATION
ALBUMIN-BINDING
business.industry
MORTALITY
lcsh:R
Hippuric acid
medicine.disease
Endocrinology
chemistry
Uric acid
business
chronic kidney disease
Kidney disease
Zdroj: TOXINS
Toxins
Toxins, Vol 11, Iss 4, p 235 (2019)
Toxins, Basel : MDPI AG, 2019, vol. 11, iss. 4, art. no. 235, p. [1-15]
Volume 11
Issue 4
Toxins, Vol. 11, no. 4, p. 235 [1-15] (2019)
ISSN: 2072-6651
Popis: Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB). In this study, we evaluated the levels and %PB of six PBUTs cross-sectionally in a large pediatric HD cohort (n = 170) by comparing these with healthy and non-dialysis chronic kidney disease (CKD) stage 4&ndash
5 (n = 24) children. In parallel &beta
2-microglobulin (&beta
2M) and uric acid (UA) were evaluated. We then explored the impact of age and residual kidney function on uremic toxin levels and %PB using analysis of covariance and Spearman correlation coefficients (rs). We found higher levels of &beta
2M, p-cresyl glucuronide (pCG), hippuric acid (HA), indole acetic acid (IAA), and indoxyl sulfate (IxS) in the HD compared to the CKD4&ndash
5 group. In the HD group, a positive correlation between age and pCG, HA, IxS, and pCS levels was shown. Residual urine volume was negatively correlated with levels of &beta
2M, pCG, HA, IAA, IxS, and CMPF (rs &minus
0.2 to &minus
0.5). In addition, we found overall lower %PB of PBUTs in HD versus the CKD4&ndash
5 group, and showed an age-dependent increase in %PB of IAA, IxS, and pCS. Furhtermore, residual kidney function was overall positively correlated with %PB of PBUTs. In conclusion, residual kidney function and age contribute to PBUT levels and %PB in the pediatric HD population.
Databáze: OpenAIRE
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