Growth arrest-specific gene 6 expression in human breast cancer
| Autor: | A. Mc Cann, O. Mc Cormack, A Mc Goldrick, Michael J. Kerin, F. J. Cooke, Patricia Fitzpatrick, B. Flynn, Peter A. Dervan, Michele Harrison, Wen Y. Chung, E. Gallagher, Edward J. Fox |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Cancer Research Progesterone receptor B growth Gene Expression Breast Neoplasms Polymerase Chain Reaction Receptor tyrosine kinase Disease-Free Survival Breast cancer breast cancer Risk Factors Progesterone receptor medicine Humans RNA Messenger growth arrest-specific gene 6 axl receptor Aged Aged 80 and over progesterone receptor b arrest-specific gene-6 gas6 receptors biology GAS6 coexpression Cancer Genetics and Genomics Middle Aged medicine.disease Survival Analysis stabilization Oncology biology.protein Cancer research Nottingham Prognostic Index Intercellular Signaling Peptides and Proteins identification cells Female activation Breast disease tyrosine kinase receptor Receptors Progesterone axl tyrosine kinase receptor |
| Zdroj: | British Journal of Cancer |
| Popis: | Growth arrest- specific gene 6 ( Gas6), identified in 1995, acts as the ligand to the Axl/ Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/ Tyro3 receptor family has been found in breast, ovarian and lung tumours. Gas6 is upregulated 23- fold by progesterone acting through the progesterone receptor B ( PRB). Recently, Gas6 has been shown to be a target for overexpression and amplification in breast cancer. Quantitative real- time PCR analysis was used to determine the levels of Gas6 mRNA expression in 49 primary breast carcinomas. Expression of PRB protein was evaluated immunohistochemically with a commercially available PRB antibody. The results showed a positive association between PRB protein and Gas6 mRNA levels ( P =0.04). Gas6 correlated positively with a number of favourable prognostic variables including lymph node negativity ( P =0.0002), younger age at diagnosis ( P =0.04), smaller size of tumours ( P =0.02), low Nottingham prognostic index scores ( P =0.03) and low nuclear morphology ( P =0.03). This study verifies for the first time the association between PRB and Gas6 in breast cancer tissue. |
| Databáze: | OpenAIRE |
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