Sodium Diuresis from Amphenone Given to Patients with Cirrhosis and Ascites
| Autor: | Bernhard B. Fast, Charles S. Davidson, James M. Stormont, Stanley J. Wolfe |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Sodium chemistry.chemical_element Diuresis Urine chemistry.chemical_compound Corticosterone Internal medicine Ascites medicine Humans Diuretics Hydrocortisone Propiophenones business.industry Thyroid Sodium Dietary General Medicine medicine.disease Endocrinology medicine.anatomical_structure chemistry medicine.symptom business medicine.drug |
| Zdroj: | New England Journal of Medicine. 257:215-218 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm195708012570504 |
| Popis: | AMPHENONE1 (1,2-bis [p-aminophenyl]-2-methyl propanone-1-dihydrochloride)∥ affects both thyroid and adrenocortical activity in animals and man.4 5 6 7 8 9 The adrenal effect is reflected in reduction of plasma hydrocortisone and corticosterone concentrations and in reduced urinary excretion of their metabolites. Studies by Peterson, Hertz and Lubs10 indicate that amphenone acts through inhibition of adrenocortical-hormone synthesis. Renold et al.11 reported that amphenone administration resulted in decreased levels of urinary aldosterone and definite sodium diuresis in a majority of 17 patients. Depressed sodium excretion in sweat, saliva and feces,12 , 13 as well as in urine of patients with hepatic cirrhosis and ascites, who also are known to excrete . . . |
| Databáze: | OpenAIRE |
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