The timing of zygotic genome activation
| Autor: | Nadine L. Vastenhouw, Máté Pálfy, Shai R. Joseph |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Genetics Genome Transcription Genetic Zygote Embryonic Development Gene Expression Regulation Developmental Embryo Biology Embryonic stem cell 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Developmental genetics Transcription (biology) Animals Maternal to zygotic transition Female Gene 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development. 43:53-60 |
| ISSN: | 0959-437X |
| DOI: | 10.1016/j.gde.2016.12.001 |
| Popis: | After fertilization, the embryonic genome is inactive until transcription is initiated during the maternal-to-zygotic transition. How the onset of transcription is regulated in a precisely timed manner, however, is a long standing question in biology. Several mechanisms have been shown to contribute to the temporal regulation of genome activation but none of them can fully explain the general absence of transcription as well the gene specific onset that follows. Here we review the work that has been done toward elucidating the mechanisms underlying the temporal regulation of transcription in embryos. |
| Databáze: | OpenAIRE |
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