Prognostic Significance of Leukopenia at the Time of Diagnosis in Acute Myeloid Leukemia
| Autor: | H. Jean Khoury, Lin Pan, Martha Arellano, Zhengjia Chen, Amelia Langston, Georgia Z. Chen, Xiangxue Guo, Mourad Tighiouart, Lisa Lima, Liliana Souza, Susan Sunay, Morgan L. McLemore, Leonard T. Heffner, Elliott F. Winton, Leon Bernal-Mizrachi |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Myeloid Adolescent Acute myelogenous leukemia (AML) Kaplan-Meier Estimate Gastroenterology Cohort Studies Young Adult hemic and lymphatic diseases Internal medicine medicine Humans Clinical significance Aged Retrospective Studies Aged 80 and over Leukopenia business.industry Remission Induction Hazard ratio Age Factors Myeloid leukemia Hematology Middle Aged Prognosis medicine.disease Confidence interval Consolidation Chemotherapy Leukemia Myeloid Acute Leukemia Treatment Outcome medicine.anatomical_structure Oncology Immunology Female medicine.symptom business Cell Adhesion Molecules |
| Zdroj: | Clinical Lymphoma Myeloma and Leukemia. 11:427-432 |
| ISSN: | 2152-2650 |
| DOI: | 10.1016/j.clml.2011.03.035 |
| Popis: | We investigated the clinical significance of leukopenia at the time of diagnosis in a cohort of 225 patients with newly diagnosed acute myeloid leukemia (AML) at a single institution. Leukocyte count was treated as a continuous variable and, using a receiver operating characteristic curve (ROC), a cutoff of 3,600/μL had the best sensitivity and specificity for remission (complete remission [CR]), relapse-free survival [RFS], and overall survival [OS]). In a multivariable model, leukopenia at diagnosis had no effects on CR (hazard ratio [HR] = 2.02; confidence interval [CI], 0.9-4.3; P = .07), RFS (HR = 0.93; CI, 0.5-1.5; P = .8), or OS (HR = 1.05; CI, 0.7-1.5; P = .7). No differential expression of cell surface molecules (CD34, c-Kit, CXCR4, PECAM, VLA2, VLA-, VLA4, VLA5, and FLT3) was observed on simultaneously obtained marrow and blood blasts in the high- vs. low-leukocyte groups. We conclude that leukopenia at diagnosis carries no prognostic significance in AML. |
| Databáze: | OpenAIRE |
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