An analysis of vascular properties using pulse wave analysis in patients with vasovagal syncope
| Autor: | Jin-Hee Park, Ji-Hun Jang, Seong-Ill Woo, Dae-Hyeok Kim, Sung Hee Shin, Sang-Don Park, Kyu-Yong Ko, Yong-Soo Baek, Jun Kwan, Sung Woo Kwon |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty pulse wave velocity Clinical Investigations Hemodynamics Blood Pressure Pulse Wave Analysis 030204 cardiovascular system & hematology augmentation index Autonomic Nervous System 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Heart Rate Internal medicine Heart rate Syncope Vasovagal Humans Medicine 030212 general & internal medicine Pulse wave velocity Vasovagal syncope business.industry General Medicine Middle Aged medicine.disease Pathophysiology vasovagal syncope Case-Control Studies Propensity score matching Arterial stiffness Cardiology Population study Female head‐up tilt Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clinical Cardiology |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.23380 |
| Popis: | Background Vasovagal syncope (VVS) is a common cause of recurrent syncope. Nevertheless, the exact hemodynamic mechanism has not been elucidated. Pulse wave analysis (PWA) is widely used to evaluate vascular properties, as it reflects the condition of the entire arterial system. Hypothesis Cardiovascular autonomic modulation may influence the hemodynamic mechanism and result in different vascular properties between VVS patients and healthy individuals. Methods We enrolled consecutive patients diagnosed with VVS on head‐up tilt testing from January 2014 to August 2019. Healthy subjects were enrolled as the control group. We performed PWA on all participants. Using propensity score matching, we assembled a study population with similar baseline characteristics and compared hemodynamic parameters. Results A total of 111 VVS patients (43 ± 18 years, 72 females) and 475 healthy control subjects (48 ± 13 years, 192 females) were enrolled. Compared to the healthy control subjects, the VVS patients had a higher augmentation index (AIx) adjusted to a heart rate of 75 beats per minute (AIx@HR75, 20.5 ± 13.1% vs 16.7 ± 11.9%, P = .003). After 1:1 matched comparison (111 matched control), VVS patients consistently showed higher AIx@HR75 (20.5 ± 13.1% vs 16.7 ± 12.9%, P = .02) than the matched control group. According to age distribution, VVS patients showed significantly higher AIx@HR75 (10.6 ± 11.7% vs 2.5 ± 11.1%, P = .01) in a young age (15‐33 years) group. Conclusions VVS patients had greater arterial stiffness than healthy subjects. This is one of the plausible mechanisms of the pathophysiology of VVS. |
| Databáze: | OpenAIRE |
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