High-sucrose diet reduces defensive reactions of the pulpo-dentinal complex to dentinal caries in young rats
| Autor: | Sisko Huumonen, Esa Pekkala, Markku Larmas, Eeva-Liisa Hietala, Tuula Bäckman, Leo Tjäderhane |
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| Rok vydání: | 2001 |
| Předmět: |
Molar
High sucrose Dentistry Weanling Dental Caries Statistics Nonparametric Streptococcus sobrinus Rats Sprague-Dawley Mandibular second molar stomatognathic system Dietary Sucrose Dentin Animals Medicine Rats Wistar General Dentistry Dental Pulp Analysis of Variance biology business.industry General Medicine Dentinogenesis biology.organism_classification Immunity Innate Rats stomatognathic diseases medicine.anatomical_structure business |
| Zdroj: | ResearcherID |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.1080/000163501750157199 |
| Popis: | The significance of systemic dietary effects on the response of the pulpo-dentinal complex to dentinal caries was examined. Weanling rats were divided into high sucrose or control diet groups both with and without cariogenic bacterial inoculation. At the onset, tetracycline was injected to mark the dentin formation during the experiment. After 5-6 week, mandibular molars were sectioned sagittally. The areas of dentin formed during the experiment and those of dentinal caries were quantified separately in the first and second molars. In the control diet groups the area of dentin was significantly greater under carious fissures, whereas in the high sucrose diet groups the area of dentin formed did not differ between intact and carious fissures. The high sucrose diet resulted in a significantly smaller area of dentin formation than did the control diet. The high sucrose diet with cariogenic bacterial inoculation resulted in the greatest area of dentinal caries. With the control diet a positive response against dentinal caries occurs, but the high dietary sucrose content impairs the defensive reactions of pulpo-dentinal complex against dentinal caries. These findings add further evidence of the importance of the local endogenous factors of caries progression. |
| Databáze: | OpenAIRE |
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