Parallel synthesis of libraries of anodic and cathodic functionalized electrodeposition paints as immobilization matrix for amperometric biosensors
Autor: | Yusif M. Sultanov, Elchin H. Aliyev, Wolfgang Schuhmann, Dmitrii A. Guschin, Bertrand Ngounou, Ayaz A. Efendiev |
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Rok vydání: | 2006 |
Předmět: |
Materials science
Polymers Pyridines Biophysics Nanotechnology Biosensing Techniques Sensitivity and Specificity Matrix (chemical analysis) Glucose Oxidase Paint Side chain Electrochemistry Glucose oxidase Physical and Theoretical Chemistry Electrodes chemistry.chemical_classification biology Imidazoles General Medicine Polymer Enzymes Immobilized Electroplating Amperometry Anode Glucose Chemical engineering chemistry biology.protein Surface modification Biosensor |
Zdroj: | Bioelectrochemistry (Amsterdam, Netherlands). 71(1) |
ISSN: | 1567-5394 |
Popis: | The integration of flexible anchoring groups bearing imidazolyl or pyridyl substituents into the structure of electrodeposition paints (EDP) is the basis for the parallel synthesis of a library containing 107 members of different cathodic and anodic EDPs with a high variation in polymer properties. The obtained EDPs were used as immobilization matrix for biosensor fabrication using glucose oxidase as a model enzyme. Amperometric glucose sensors based on the different EDPs showed a wide variation in their sensor characteristics with respect to the apparent Michaelis–Menten constant ( K M app ) representing the linear measuring range and the maximum current ( I max app ). Based on these results first assumptions concerning the impact of different side chains in the EDP on the expected biosensor properties could be obtained allowing for an improved rational optimization of EDPs used as immobilization matrix in amperometric biosensors. |
Databáze: | OpenAIRE |
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