Effects of Anticoagulation Intensity on Hemostatic Markers in Patients With Non-Valvular Atrial Fibrillation
| Autor: | Ken Okumura, Lee Jong-Dae, Hiroshi Inoue, Motonobu Hayano, Akihiko Shimizu, Katsusuke Yano, Atsushi Iwasa, Takashi Nozawa |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Platelet Factor 4 Fibrin Fibrin Fibrinogen Degradation Products Age Distribution Internal medicine Atrial Fibrillation Humans Medicine Sinus rhythm In patient cardiovascular diseases Adverse effect Aged Aged 80 and over Hemostasis Dose-Response Relationship Drug biology business.industry Warfarin Anticoagulants Atrial fibrillation General Medicine Middle Aged beta-Thromboglobulin medicine.disease Intensity (physics) biology.protein Cardiology Cardiology and Cardiovascular Medicine business Biomarkers Platelet Aggregation Inhibitors Platelet factor 4 medicine.drug |
| Zdroj: | Circulation Journal. 68:29-34 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND Elevation of hemostatic markers may account for the increased risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). The aim of this study was to determine the effects of anticoagulation intensity on hemostatic markers in patients with NVAF. METHODS AND RESULTS In 509 patients with NVAF, comprising 263 patients treated with warfarin and 246 patients without warfarin, the hemostatic markers of prothrombin fragment F1.2 (F1.2), fibrin D-dimer, platelet factor 4 (PF4), and beta-thromboglobulin were determined and compared with those in 111 patients with sinus rhythm. F1.2 was inversely related with anticoagulation intensity and D-dimer increased with age. All hemostatic markers, except F1.2, were greater in patients with NVAF than in patients with sinus rhythm. F1.2 and D-dimer were significantly lower in patients with international normalized ratio (INR) > or =1.5 than in NVAF patients without warfarin and were not different between NVAF patients with INR of 1.5-1.9 and with INR > or =2.0. CONCLUSIONS Low intensity of anticoagulation (INR 1.5-1.9) suppresses the elevated concentration of F1.2 and D-dimer in patients with NVAF, and might be favorable in Japanese patients with NVAF in view of the balance between prevention of thromboembolism and the adverse effect by warfarin (ie, bleeding). |
| Databáze: | OpenAIRE |
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