Efficacy and Safety of Lysozyme, Cetylpyridinium and Lidocaine Fixed Combination for Treatment of Chemotherapy- and Radiotherapy-Induced Oral Mucositis: a Pilot Study
| Autor: | Belma Kapo, Alma Mekic-Abazovic, Asmir Avdicevic, Slobodan M. Jankovic, Aida Lokvancic, Azra Rasic |
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| Rok vydání: | 2019 |
| Předmět: |
Original Paper
medicine.medical_specialty Chemotherapy treatment Lidocaine business.industry medicine.medical_treatment Cetylpyridinium chemotherapy Recurrent aphthous stomatitis medicine.disease chemistry.chemical_compound chemistry Internal medicine Mucositis Medicine Lysozyme business Adverse effect Prospective cohort study lysozyme radiotherapy oral mucositis medicine.drug |
| Zdroj: | Materia Socio-Medica |
| ISSN: | 1512-7680 |
| Popis: | Introduction Beneficial effect of local administration of lysozyme in patients with recurrent aphthous stomatitis was demonstrated, but there are no published studies focused on treatment of chemotherapy or radiotherapy induced oral mucositis with lysozyme. Aim The aim of this study was to compare efficacy and safety of Lysobact Complete spray (lysozyme, cetylpyridinium, and lidocaine) and compounded medication for local use in the treatment of radio- and chemo-therapy induced oral mucositis. Patients and methods This observational, phase IV study was designed as prospective cohort investigation, and conducted at two sites, Clinical Hospital Zenica and University Clinical Center Tuzla, Bosnia & Herzegovina, from August to November, 2018. The patients with oral mucositis after radio- or chemo-therapy were treated by either registered lysozyme-based or compounded medication (standardized and bicarbonate-based) for 21 days. Results Both lysozyme-based (Lysobact Complete Spray) spray (lysozyme, cetylpyridinium and lidocaine) and compounded medication for local use were effective in local treatment of chemotherapy and radiotherapy-induced oral mucositis. However, lysozyme-based preparation was more effective, since signs of inflammation, number of oral ulcers and intensity of pain during eating and speaking withdrew to a greater extent than with highly variable compounded medication for local use. No adverse events were recorded in both treatment arms. Conclusions Locally administered spray with fixed combination of lysozyme, cetylpyridinium and lidocaine (Lysobact Complete Spray) is very efficient and completely safe treatment of both radiotherapy and chemotherapy-induced oral mucositis. |
| Databáze: | OpenAIRE |
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