Iron bioavailability of four iron sources used to fortify infant cereals, using anemic weaning pigs as a model
| Autor: | Silvia Martínez Miró, Carlos Alberto González Bermúdez, Rubén López Nicolás, Carmen Martínez Graciá, Guillermo Doménech Asensi, Ana María Caballero Valcárcel, Marina Santaella Pascual, Josefa Madrid Sánchez |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Anemia Swine Fortification Medicine (miscellaneous) Biological Availability 030209 endocrinology & metabolism Weaning Ferrous Fumarate 03 medical and health sciences 0302 clinical medicine Animal science medicine Animals 030109 nutrition & dietetics Nutrition and Dietetics biology Chemistry medicine.disease Bioavailability Ferritin Disease Models Animal Food Fortified biology.protein Infant Food Iron status Hemoglobin Edible Grain Iron Dietary medicine.drug |
| Zdroj: | European journal of nutrition. 58(5) |
| ISSN: | 1436-6215 |
| Popis: | Iron (Fe) deficiency anemia in young children is a global health concern which can be reduced by Fe fortification of foods. Cereal is often one of the first foods given to infants, providing adequate quantities of Fe during weaning. In this work, we have compared iron bioavailability and iron status of four iron sources used to fortify infant cereals, employing piglets as an animal model. The study was conducted on 36 piglets, 30 of them with induced anemia. From day 28 of life, the weaned piglets were fed with four experimental diets (n = 6) each fortified with 120 mg Fe/kg by ferrous sulfate heptahydrate (FSH), electrolytic iron (EI), ferrous fumarate (FF), or micronized dispersible ferric pyrophosphate (MDFP) for another 21 days. In addition, one group of six anemic piglets fed with the basal diet with no iron added (Control−) and a Control+ group of non-anemic piglets (n = 6) were also studied. Blood indicators of iron status were measured after depletion and during the repletion period. The Fe content in organs, hemoglobin regeneration efficiency, and relative bioavailability (RBV) was also determined. The Fe salts adequately treated anemia in the piglets, allowing the animals to recover from the anemic state, although EI was less efficient with regard to replenishing Fe stores giving lower concentrations of plasma ferritin and iron in the spleen, liver, lung, and kidney. In addition, the RBV of EI was 88.27% with respect to the reference iron salt (FSH). Ferrous fumarate and MDFP were equally as bioavailable as the reference salt, and were used significantly better than EI in piglets. These results contribute to extend the evidence-based results for recommending the most suitable fortificant for infant cereals. |
| Databáze: | OpenAIRE |
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