Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer’s Disease
| Autor: | Bogdan-Ionel Tamba, Andrei Luca, Luminita Paduraru, Raluca Stefanescu, Gabriela Dumitriṭa Stanciu |
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| Rok vydání: | 2020 |
| Předmět: |
naturally occurring polyphenol compounds
Genetically modified mouse lcsh:QR1-502 Silibinin Mice Transgenic Review Biochemistry Catechin lcsh:Microbiology beta-amyloid aggregation inhibitors Mice Protein Aggregates 03 medical and health sciences chemistry.chemical_compound neurodegenerative disease 0302 clinical medicine Alzheimer Disease medicine Animals Benzothiazoles Cognitive decline Luteolin Molecular Biology Fluorescent Dyes 030304 developmental biology Flavonoids chemistry.chemical_classification Biological Products 0303 health sciences Amyloid beta-Peptides Fibrillogenesis medicine.disease Amino acid transgenic mouse model chemistry Silybin Myricetin Thioflavin Cerebral amyloid angiopathy Alzheimer’s disease 030217 neurology & neurosurgery |
| Zdroj: | Biomolecules, Vol 10, Iss 870, p 870 (2020) Biomolecules |
| ISSN: | 2218-273X |
| DOI: | 10.3390/biom10060870 |
| Popis: | Alzheimer’s disease is a neurodegenerative disorder for which there is a continuous search of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed of 40 and 42 amino acids and are considered a major cause of neuronal toxicity. They are prone to aggregation, yielding oligomers and fibrils through the inter-molecular binding between the amino acid sequences (17–42) of multiple amyloid-beta molecules. Additionally, amyloid deposition causes cerebral amyloid angiopathy. The present study aims to identify, in the existing literature, natural plant derived products possessing inhibitory properties against aggregation. The studies searched proved the anti-aggregating effects by the thioflavin T assay and through behavioral, biochemical, and histological analysis carried out upon administration of natural chemical compounds to transgenic mouse models of Alzheimer’s disease. According to our present study results, fifteen secondary metabolites from plants were identified which presented both evidence coming from the thioflavin T assay and transgenic mouse models developing Alzheimer’s disease and six additional metabolites were mentioned due to their inhibitory effects against fibrillogenesis. Among them, epigallocatechin-3-gallate, luteolin, myricetin, and silibinin were proven to lower the aggregation to less than 40%. |
| Databáze: | OpenAIRE |
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