Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology
| Autor: | Giorgia Iacolino, Chiara Bellia, Luisa Agnello, Giulia Bivona, Marcello Ciaccio, Concetta Scazzone, Bruna Lo Sasso |
|---|---|
| Přispěvatelé: | Giulia Bivona, Luisa Agnello, Chiara Bellia, Giorgia Iacolino, Concetta Scazzone, Bruna Lo Sasso, Marcello Ciaccio |
| Rok vydání: | 2019 |
| Předmět: |
Medicine (General)
Parkinson's disease Physiology vitamin D Disease Review Secosteroid brain function chemistry.chemical_compound 25(OH)D3 R5-920 Immune system Alzheimer Disease Vitamin D and neurology Medicine Humans Secosteroids Brain function business.industry Parkinson Disease General Medicine medicine.disease Vitamin D Deficiency immune system chemistry Parkinson’s disease Biomarker (medicine) business Alzheimer’s disease Biomarkers Hormone |
| Zdroj: | Medicina Medicina, Vol 55, Iss 7, p 341 (2019) |
| ISSN: | 1648-9144 |
| Popis: | Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development. Low blood vitamin D levels have been reported in patients affected by various diseases. Despite a large amount of literature data, there is uncertainty surrounding the role of vitamin D as a serum biomarker in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the lack of internationally recognized 25(OH)D3 reference measurement procedures and standard materials in the past led to unstandardized serum total 25(OH)D3 results among research and clinical care laboratories. Thus, most of the literature studies reported unstandardized data, which are of little use and make it difficult to draw conclusions of the role of vitamin D in AD and PD. This review summarizes the extra-skeletal actions of vitamin D, focusing its role in immunomodulation and brain function, and reports the issue of lacking standardized literature data concerning the usefulness of vitamin D as a biomarker in AD and PD. |
| Databáze: | OpenAIRE |
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